Dienestrol

Dienestrol is a synthetic non-steroidal estrogen receptor (ER) agonist and an active metabolite of diethylstilbestrol (Cay-10006876). Dienestrol binds to ERalpha and ERbeta (Kis = 0.05 and 0.03 nM, respectively) and activates ERalpha in a reporter assay (EC50 = 3.23 nM). It also inhibits porcine microtubule assembly and induces disassembly of preformed microtubules when used at concentrations of 50 and 100 µM, respectively, in cell-free assays. Oral administration of dienestrol (1.5-6.25 µg/kg) to pregnant rats during gestation and lactation decreases sperm motility and viability and induces prostatitis in mature male offspring. It induces abortions when administered to pregnant rats at 50 and 75 µg/kg. Formulations containing dienestrol have been used in the treatment of atrophic vaginitis and vulvar atrophy.Formal Name: 4,4'-(1,2-diethylidene-1,2-ethanediyl)bis-phenol. CAS Number: 84-17-3. Synonyms: Dienoestrol, NSC 59809. Molecular Formula: C18H18O2. Formula Weight: 266.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: OC1=CC=C(C(C(C2=CC=C(C=C2)O)=CC)=CC)C=C1. InChi Code: InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3. InChi Key: NFDFQCUYFHCNBW-UHFFFAOYSA-N.