Zu "K08551" wurden 205 Artikel gefunden!
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Tamoxifen
Artikelnummer: Cay13258-5
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Schlagworte: | 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-ethanamine |
| Anwendung: | Estrogen receptor modulator |
| CAS | 10540-29-1 |
| MW: | 371.5 D |
ab 97,00 €
(E/Z)-4-hydroxy Tamoxifen
Artikelnummer: Cay17308-50
(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Cay-13258). It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively). It also stimulates LC3 lipidation and the...
| Schlagworte: | 4-hydroxy Tamoxifen, 4-OHT, Afimoxifene, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol |
| Anwendung: | Active tamoxifen metabolite, estrogen receptor agonist/antagonist |
| CAS | 68392-35-8 |
| MW: | 387.5 D |
ab 57,00 €
Tamoxifen (citrate)
Artikelnummer: Cay11629-5
Tamoxifen is an estrogen receptor antagonist (IC50 = 45 nM for the rabbit receptor). It reduces the proliferation of MCF-7 breast cancer cells when used at a concentration of 10 µM. Tamoxifen is active against S. cerevisiae, C. neoformans, and five Candida species (MICs = 12, 64, and 8-64 µg/ml, respectively). It...
| Schlagworte: | ICI 46474, Istubal, Kessar, Noltam, Nolvadex, TMX, Valodex, Zemide,... |
| Anwendung: | Estrogen receptor (ER) modulator, Apoptosis inducer |
| CAS | 54965-24-1 |
| MW: | 563.6 D |
ab 67,00 €
Tamoxifen
Artikelnummer: CDX-T0200-G005
Synthetic. Chemical. CAS: 10540-29-1. Formula: C26H29NO. MW: 371.51. Synthetic. Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the cardiovasculature...
| Schlagworte: | (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine |
| Anwendung: | Selective estrogen receptor modulator |
| CAS | 10540-29-1 |
| MW: | 371,51 D |
ab 77,00 €
Erteberel
Artikelnummer: Cay22130-1
Erteberel is an estrogen receptor beta (ERbeta) agonist. It is selective for ERbeta over ERalpha in reporter assays using PC3 cells expressing the human receptors (EC50s = 0.66 and 19.4 nM, respectively). Ertebrel (5 µM) induces apoptosis and cell cycle arrest at the G2/M phase in U87MG and U251 glioblastoma cells....
| Schlagworte: | LY500307, (3aS,4R,9bR)-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-cyclopenta[c][1]benzopyran-8-ol |
| Anwendung: | Estrogen receptor beta agonist |
| CAS | 533884-09-2 |
| MW: | 282.3 D |
ab 108,00 €
Hexestrol-d6
Artikelnummer: Cay43149-1
Hexestrol-d6 is intended for use as an internal standard for the quantification of hexestrol (Cay-29003) by GC- or LC-MS. Hexestrol is a synthetic non-steroidal estrogen receptor ligand that binds to estrogen receptor alpha (ERalpha) and ERbeta (Kis = 0. and 0. nM for the human and rat receptors, respectively). It...
| Schlagworte: | Hexoestrol-d6, meso-Hexestrol-d6, 4,4'-(hexane-3,4-diyl-2,2,3,4,5,5-d6)diphenol |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification, synthetic non-steroidal estrogen receptor ligand |
| CAS | 1219798-48-7 |
| MW: | 276.41 D |
ab 147,00 €
Bazedoxifene (acetate)
Artikelnummer: Cay15005-5
Bazedoxifene (acetate) is a third generation selective estrogen receptor modulator (SERM). It is an indole-based ER ligand that binds to both ERalpha (IC50 = 26 nM) and ERbeta (IC50 = 99 nM). Bazedoxifene (actetate) antagonizes 17beta-estradiol-dependent MCF-7 and T47D breast cancer cell proliferation in vitro as...
| Schlagworte: | TSE 424, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol, acetate |
| Anwendung: | Selective estrogen receptor modulator |
| CAS | 198481-33-3 |
| MW: | 530.7 D |
ab 166,00 €
(±)-Equol
Artikelnummer: Cay13184-10
Equol is a nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora. The estrogen receptor (ER) binding activity of the naturally occurring (S)-enantiomer demonstrates greater affinity toward ERbeta while the (R)-enantiomer demonstrates greater...
| Schlagworte: | 3,4-dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol |
| Anwendung: | Estrogen receptor agonist |
| CAS | 94105-90-5 |
| MW: | 242.3 D |
ab 50,00 €
Zearalanone
Artikelnummer: Cay19459-5
Zearalanone is a mycotoxin, an estrogen receptor (ER) agonist, and an active metabolite of alpha-zearalanol (Cay-23424) and the mycotoxin zearalenone (Cay-11353). Zearalanone induces reporter gene expression in S. cerevisiae expressing human ER (EC50 = 110 nM). It is also an androgen receptor antagonist (IC50 =...
| Schlagworte: | (3S)-3,4,5,6,9,10,11,12-octahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione |
| Anwendung: | Estrogen receptor agonist, androgen receptor antagonist |
| CAS | 5975-78-0 |
| MW: | 320.4 D |
ab 73,00 €
ERbeta (human) Reporter Assay Kit
Artikelnummer: IB-IB00411
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the full-length human estrogen receptor 2 (NR3A2), a ligand-dependent transcription factor commonly referred to as ERbeta. INDIGO's reporter cells include the luciferase reporter gene...
| Schlagworte: | ESR2, ESTRB, ER-beta, Estrogen receptor beta, Nuclear receptor subfamily 3 group A member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
Hexestrol
Artikelnummer: LKT-H1894.1
A carcinogenic synthetic estrogen that inhibits microtubule polymerization and the formation of ribbon structures. It is an inhibitor of lipid peroxidation.
| Schlagworte: | Dihydrodiethylstilbestrol |
| Anwendung: | Lipid peroxidation inhibitor |
| CAS | 84-16-2 |
| MW: | 270,37 D |
ab 100,00 €
8-Prenylnaringenin
Artikelnummer: Cay17462-5
8-Prenylnaringenin (8-PN) is a prenylflavonoid with potent estrogenic activity that can be isolated from hops. It inhibits both isoforms of the human estrogen receptor (ER, IC50s = 57 and 68 nM for ERalpha and ERbeta, respectively). 8-PN is effective in vivo, suppressing loss of bone mineral density in...
| Schlagworte: | (±)-8-PN, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one |
| Anwendung: | Estrogen receptor inhibitor |
| CAS | 68682-02-0 |
| MW: | 340.4 D |
ab 77,00 €