desbutyl Lumefantrine

desbutyl Lumefantrine is an active metabolite of the antimalarial agent lumefantrine (Cay-20678). It is formed from lumefantrine by the cytochrome P450 (CYP) isoform CYP3A4. desbutyl Lumefantrine is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50s = 9 and 9.5 nM, respectively). It inhibits the human-ether-a-go-go (hERG) potassium channel, also known as Kv11.1, in HEK293 cells expressing the human channel (IC50 = 5.49 µM).Formal Name: (9Z)-alpha-[(butylamino)methyl]-2,7-dichloro-9-[(4-chlorophenyl)methylene]-9H-fluorene-4-methanol. CAS Number: 355841-11-1. Synonyms: DBB, DBL, desbutyl Benflumetol, monodesbutyl Benflumetol. Molecular Formula: C26H24Cl3NO. Formula Weight: 472.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: slightly, sonicated, DMSO: slightly. SMILES: OC(CNCCCC)C1=C(C(C=CC(Cl)=C2)=C2/C3=C/C4=CC=C(Cl)C=C4)C3=CC(Cl)=C1. InChi Code: InChI=1S/C26H24Cl3NO/c1-2-3-10-30-15-25(31)24-14-19(29)13-23-21(11-16-4-6-17(27)7-5-16)22-12-18(28)8-9-20(22)26(23)24/h4-9,11-14,25,30-31H,2-3,10,15H2,1H3/b21-11-. InChi Key: YLBUTQNEBVPTES-NHDPSOOVSA-N.