Zu "K17689" wurden 120 Artikel gefunden!
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4-hydroxy Alprazolam
Artikelnummer: Cay15878-1
Alprazolam is a benzodiazepine with anxiolytic and sedative actions. 4-Hydroxyalprazolam is a major metabolite of alprazolam, produced by the actions of cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5. It may be detected in serum or, in a glucuronidated form, in urine. Alternatively, 4-hydroxyalprazolam can be...
| Schlagworte: | 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-ol |
| Anwendung: | Alprazolam metabolite |
| CAS | 30896-57-2 |
| MW: | 324.8 D |
ab 61,00 €
CYP3A4 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPY-05321-100ug
Description: CYP3A4 is an important member of the cytochrome P450 enzyme superfamily, with 33 allelic variants. Human cytochrome P450 3A4 (CYP3A4) is an important drug metabolizing enzyme involved in a number of drug-drug and food-drug interactions. Systemic inflammation has been linked to suppressed CYP3A4 activity.
| Schlagworte: | CP34, CYPIIIA4, P450C3, P450PCN1, cytochrome P450 family 3 subfamily A member 4, CYP3A, CYP3A3, CYPIIIA3, NF-25, HLP, CP33 |
| MW: | 59.2 kD |
ab 699,00 €
ML368
Artikelnummer: TGM-T25823-1mg
Description: ML368 is a selective inhibitor of CYP3A4. Target: Others. Smiles: O=C(Nc1ccc(cc1)-c1ccc(cc1)C#N)Nc1ccc(cc1)-c1ccnc2[nH]cnc12. References: Cameron M, Kamenecka T, Madoux F, Chase P, Roush W, Hodder P, Griffin PR. ML368 Identification of Imidazopyridines as Selective Inhibitors of the Cytochrome P450...
| Schlagworte: | SR-9186, ML 368, SR9186, SR 9186, ML-368 |
| Anwendung: | Selective CYP3A4 inhibitor |
| CAS | 1361414-26-7 |
| MW: | 430.46 D |
1.289,00 €
alpha-Hydroxytamoxifen
Artikelnummer: TGM-T19192-10mg
Description: alpha-Hydroxytamoxifen, a metabolite of tamoxifen, reacts with DNA and forms DNA adducts. Target: Others. Smiles: C(=C(/C(C)O)\C1=CC=CC=C1)(\C2=CC=C(OCCN(C)C)C=C2)/C3=CC=CC=C3. References: Phillips DH, et al. alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity...
| Schlagworte: | alpha-OHTAM, (E)-alpha-Hydroxy tamoxifen |
| Anwendung: | Reactive tamoxifen metabolite |
| CAS | 97151-02-5 |
| MW: | 387.51 D |
ab 77,00 €
N-Acetyl-4-benzoquinone imine
Artikelnummer: Cay16115-500
N-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of...
| Schlagworte: | N-Acetyl-p-benzoquinonimine, NAPQI, N-(4-oxo-2,5-cyclohexadien-1-ylidene)-acetamide |
| Anwendung: | Paracetamol metabolite |
| CAS | 50700-49-7 |
| MW: | 149.2 D |
ab 161,00 €
Axitinib sulfoxide
Artikelnummer: TGM-T21129-1mg
Description: Axitinib sulfoxide is a major metabolite of Axitinib, which is a VEGFR tyrosine kinase inhibitor and may be useful in cancer therapy. Target: Others. Smiles: C(=C/C1=CC=CC=N1)\C=2C=3C(=CC(S(=O)C4=C(C(NC)=O)C=CC=C4)=CC3)NN2. References: Slobbe P, Poot AJ, Haumann R, Schuit RC, Windhorst AD, van Dongen...
| Schlagworte: | PF-03482595, AG-028458, Axitinib metabolite M12 |
| Anwendung: | Major inactive metabolite |
| CAS | 1347304-18-0 |
| MW: | 402.47 D |
ab 154,00 €
21-hydroxy Eplerenone
Artikelnummer: TGM-T36129-1mg
Description: 21-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone . It is formed from eplerenone by the cytochrome P450 (CYP) isoform CYP3A4. Target: Others. Smiles:...
| Anwendung: | Major eplerenone metabolite |
| CAS | 334678-67-0 |
| MW: | 430.497 D |
839,00 €
N-Desethyl Vardenafil
Artikelnummer: TGM-T35714-1mg
Description: N-Desethyl vardenafil is a metabolite of vardenafil , a phosphodiesterase 5 inhibitor, that is formed by the action of cytochrome P450 (CYP)3A4 and CYP3A5. Target: Others. Smiles: O=C1N=C(NN2C(=NC(=C12)C)CCC)C=3C=C(C=CC3OCC)S(=O)(=O)N4CCNCC4
| Anwendung: | Vardenafil metabolite |
| CAS | 448184-46-1 |
| MW: | 460.55 D |
ab 77,00 €
N-desmethyl Eletriptan
Artikelnummer: TGM-T35715-1mg
Description: N-Desmethyl Eletriptan, a metabolite of eletriptan, is primarily formed from eletriptan by the cytochrome P450 (CYP) isoform CYP3A4 in human liver microsomes. Target: Others. Smiles: O=S(=O)(CCc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1)c1ccccc1. References: Evans, D.C., O'Connor, D., Lake, B.G., et al.Eletriptan...
| Anwendung: | Eletriptan metabolite |
| CAS | 153525-55-4 |
| MW: | 368.5 D |
266,00 €
4-hydroxy Atorvastatin (calcium salt)
Artikelnummer: TGM-T35724-1mg
Description: 4-hydroxy Atorvastatin is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin. Target:...
| Anwendung: | Atorvastatin metabolite |
| CAS | 265989-44-4 |
| MW: | 1191.393 D |
ab 198,00 €
Monocrotaline
Artikelnummer: TGM-T2803-100mg
Description: Monocrotaline (Crotaline) is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary...
| Schlagworte: | Crotaline |
| Anwendung: | Pulmonary hypertension inducer |
| CAS | 315-22-0 |
| MW: | 325.36 D |
ab 42,00 €
Imidafenacin Metabolite M4
Artikelnummer: TGM-T36662-1mg
Description: Imidafenacin metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist imidafenacin.1It is formed from imidafenacin by the cytochrome P450 (CYP) isoform CYP3A4. Target: Others. Smiles: NC(=O)C(=O)NCCC(C(N)=O)(c1ccccc1)c1ccccc1. References: Kanayama, N., Kanari, C., Masuda, Y., et...
| Schlagworte: | Imidafenacin Metabolite M4 |
| Anwendung: | Imidafenacin metabolite |
| CAS | 503598-17-2 |
| MW: | 325.368 D |
ab 275,00 €