Danusertib

Danusertib is a pan-Aurora kinase inhibitor (IC50s = 13, 79, and 61 nM for Aurora A, B, and C, respectively) that also targets Abl, Ret, TrkA and FGFR1 (IC50s = 25, 31, 31, and 47 nM, respectively). It exhibits anti-proliferative and pro-apoptotic activity against a panel of cancer cells in vitro, including those expressing wild type and mutant Bcr-Abl. Danusertib is effective against diverse xenografts in mice, including those containing mutant Bcr-Abl that are resistant to imatinib (Cay-13139).Formal Name: 4-(4-methyl-1-piperazinyl)-N-[1,4,5,6-tetrahydro-5-[(2R)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3-yl]-benzamide. CAS Number: 827318-97-8. Synonyms: PHA-739358. Molecular Formula: C26H30N6O3. Formula Weight: 474.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 20 mg/ml, Ethanol: 25 mg/ml. lambdamax: 310 nm. SMILES: CN1CCN(C2=CC=C(C(NC3=NNC4=C3CN(C([C@H](OC)C5=CC=CC=C5)=O)C4)=O)C=C2)CC1. InChi Code: InChI=1S/C26H30N6O3/c1-30-12-14-31(15-13-30)20-10-8-19(9-11-20)25(33)27-24-21-16-32(17-22(21)28-29-24)26(34)23(35-2)18-6-4-3-5-7-18/h3-11,23H,12-17H2,1-2H3,(H2,27,28,29,33)/t23-/m1/s1. InChi Key: XKFTZKGMDDZMJI-HSZRJFAPSA-N.