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Zu "K11479" wurden 111 Artikel gefunden!
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Artikelnummer: ELK-ELK4635.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human AURKB. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human AURKB. Next,...
Schlagworte: | STK-1, ARK-2, AURKB, AIM-1, Aurora 1, Aurora kinase B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2,... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: BPS-82094
The Chemi-Verse(TM) Aurora Kinase B Assay Kit is a luminescence assay designed to measure Aurora Kinase B kinase activity for screening and profiling applications using ADP-Glo(TM) as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant Aurora Kinase B, kinase...
Schlagworte: | AURKB, STK-1, ARK-2, AIM-1, Aurora 1, Aurora kinase B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2,... |
Anwendung: | Enzyme kinetics, kinase assay, small molecule inhibitor screening, drug discovery, HTS |
Spezies-Reaktivität: | human |
1.496,00 €
Artikelnummer: Cay13601-10
The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin. ZM 447439 is a selective inhibitor of Aurora B kinase (IC50 = 50 nM), less potently inhibiting Aurora C and A...
Schlagworte: | N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-benzamide |
Anwendung: | Aurora B kinase inhibitor |
CAS | 331771-20-1 |
MW: | 513.6 D |
ab 82,00 €
Artikelnummer: 600-401-677
Protein function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced...
Schlagworte: | Anti-phospho-AIK2, Anti-phospho-AURKB, Anti-phospho-ARK-2, Anti-phospho-STK-1, Anti-phospho-AIM-1, Anti-phospho-Aurora 1,... |
Anwendung: | ELISA, IHC, IFM, WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 180,00 €
Artikelnummer: Cay19176-1
Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Their expression is elevated in a variety of human cancers. AMG 900 is an orally bioavailable, selective Aurora kinase inhibitor with IC50 values of 5, 4, and 1 nM for Aurora A, B, and C, respectively....
Schlagworte: | N-[4-[[3-(2-amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine |
Anwendung: | Aurora kinase inhibitor |
CAS | 945595-80-2 |
MW: | 503.6 D |
ab 60,00 €
Artikelnummer: A300-431A
Protein function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced...
Schlagworte: | Anti-AIK2, Anti-STK-1, Anti-AIM-1, Anti-AURKB, Anti-ARK-2, Anti-Aurora 1, EC=2.7.11.1, Anti-Aurora kinase B,... |
Anwendung: | WB, IP, ICC-IF |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: SYN-1092-M001
Soluble in DMSO or ethanol. In mammals, three Aurora kinases, Aurora A, Aurora B, and Aurora C, are expressed. Aurora C expression is mainly restricted to testis, where it functions during meiosis, whereas Aurora A and B play key functions regulating mitosis. Aurora A is localized to the centrosome and spindle...
Schlagworte: | MK-0457, VX-680 |
Anwendung: | Aurora inhibitor |
CAS | 639089-54-6 |
MW: | 464,6 D |
ab 66,00 €
Artikelnummer: BPS-40002
Active human Aurora kinase B (GenBank Accession No. NM_004217), (a.a. 2- 344), with N-terminal GST-HIS6-tag , expressed in a Baculovirus infected Sf9 cell expression system. The theoretical MW is 70 kDa.
Schlagworte: | AURKB, STK-1, ARK-2, AIM-1, Aurora 1, Aurora kinase B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2,... |
Anwendung: | Enzyme kinetics, inhibitor screening |
MW: | 70 kD |
525,00 €
Artikelnummer: Cay13647-1
AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50 = 0.36 nM). AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis...
Schlagworte: | Barasertib,... |
Anwendung: | Aurora kinase B inhibitor prodrug |
CAS | 722543-50-2 |
MW: | 660.5 D |
ab 32,00 €
Artikelnummer: Cay24199-1
Hesperadin is a multi-kinase inhibitor. It inhibits human Aurora kinase B (IC50 = 250 nM) and its T. brucei homolog Aurora kinase-1 (IC50 = 40 nM) in in vitro kinase assays. Hesperadin (1 µM) inhibits AMPK, LCK, MKK1, MAPKAP-K1, CHK1, and PHK in a panel of 25 kinases. It also inhibits MEKK2 in ATPase and...
Schlagworte: | N-[2,3-dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-ethanesulfonamide |
Anwendung: | Multi-kinase inhibitor |
CAS | 422513-13-1 |
MW: | 516.7 D |
ab 66,00 €
Artikelnummer: Cay18387-1
Danusertib is a pan-Aurora kinase inhibitor (IC50s = 13, 79, and 61 nM for Aurora A, B, and C, respectively) that also targets Abl, Ret, TrkA and FGFR1 (IC50s = 25, 31, 31, and 47 nM, respectively). It exhibits anti-proliferative and pro-apoptotic activity against a panel of cancer cells in vitro, including those...
Schlagworte: | PHA-739358,... |
Anwendung: | Aurora kinase inhibitor |
CAS | 827318-97-8 |
MW: | 474.6 D |
ab 60,00 €
Artikelnummer: Cay22953-1
GSK1070916 is a potent and ATP-competitive inhibitor of Aurora kinases B and C (Kis = 0.38 and 1.5 nM, respectively). It is >250-fold selective for Aurora B and C over Aurora A. GSK1070916 inhibits proliferation of A549 lung cancer cells in vitro (EC50 = 7 nM). It also inhibits proliferation in a panel of 100 tumor...
Schlagworte: | N'-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethyl-... |
Anwendung: | Aurora B/C kinase inhibitor |
CAS | 942918-07-2 |
MW: | 507.6 D |
ab 54,00 €