Zu "K11479" wurden 119 Artikel gefunden!
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CCT 137690
Artikelnummer: TGM-T2611-100mg
Description: CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM). Target: Apoptosis, Aurora Kinase. Smiles: CN1CCN(CC1)c1ccc(cc1)-c1nc2c(N3CCN(Cc4cc(C)on4)CC3)c(Br)cnc2[nH]1. References: Bavetsias V, et al. J Med Chem, 2010, 53(14),...
| Schlagworte: | CCT137690 |
| Anwendung: | Aurora kinase inhibitor |
| CAS | 1095382-05-0 |
| MW: | 551.48 D |
ab 52,00 €
Hesperadin
Artikelnummer: TGM-T6532-10mg
Description: Hesperadin(IC50=250 nM) effectively inhibits Aurora B. It potently reduces the activity of AMPK, MAPKAP-K1, MKK1, Lck, CHK1 and PHK, but it could not inhibit MKK1 activity in vivo. Target: Parasite, Aurora Kinase, Autophagy, Influenza Virus. Smiles:...
| Anwendung: | Multi-kinase inhibitor |
| CAS | 422513-13-1 |
| MW: | 516.65 D |
ab 34,00 €
CCT129202
Artikelnummer: TGM-T6435-100mg
Description: CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 µM, 0.198 µM and 0.227 µM, respectively. It is less potent to FGFR3, GSK3beta, PDGFRbeta, etc. Target: Aurora Kinase. Smiles: CN(C)c1ccc(cc1)-c1nc2c(N3CCN(CC(=O)Nc4nccs4)CC3)c(Cl)cnc2[nH]1....
| Anwendung: | Aurora kinase inhibitor |
| CAS | 942947-93-5 |
| MW: | 497.02 D |
ab 40,00 €
AMG 900
Artikelnummer: TGM-T6380-100mg
Description: AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 values of 5 nM, 4 nM, and 1 nM, respectively. It exhibits over 10-fold selectivity for Aurora kinases compared to p38alpha, Tyk2, JNK2, Met, and Tie2. [Phase 1]. Target: p38 MAPK, Tyrosine Kinases, Aurora...
| Schlagworte: | AMG-900, AMG900 |
| Anwendung: | Aurora kinase inhibitor |
| CAS | 945595-80-2 |
| MW: | 503.58 D |
ab 45,00 €
Aurora kinase inhibitor-10
Artikelnummer: TGM-T63853-100mg
Description: Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects. Target: Others. Smiles: OC(=O)C(F)(F)F.NS(=O)(=O)c1ccc(Nc2ncc(F)c(n2)N2CCNc3cc(F)ccc3C2)cc1
| Anwendung: | Aurora kinase inhibitor |
| CAS | 2417228-90-9 |
| MW: | 546.47 D |
ab 1.520,00 €
BI-847325
Artikelnummer: TGM-T6785-100mg
Description: BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. Target: Aurora Kinase, Apoptosis, MEK. Smiles: CCNC(=O)C#Cc1ccc2\C(=C(\Nc3ccc(CN(C)C)cc3)c3ccccc3)C(=O)Nc2c1. References: Phadke MS, et al. Mol Cancer Ther....
| Anwendung: | MEK / Aurora kinase inhibitor |
| CAS | 1207293-36-4 |
| MW: | 464.56 D |
ab 45,00 €
GSK-1070916
Artikelnummer: TGM-T6129-100mg
Description: GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1. Target: FLT, Apoptosis, Aurora Kinase, Tie-2, AMPK. Smiles:...
| Schlagworte: | GSK-1070916A, GSK1070916 |
| Anwendung: | Aurora B/C kinase inhibitor |
| CAS | 942918-07-2 |
| MW: | 507.63 D |
ab 42,00 €
ZM-447439
Artikelnummer: TGM-T6077-100mg
Description: ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc. Target: Aurora Kinase, Apoptosis, MEK, Src....
| Anwendung: | Aurora B kinase inhibitor |
| CAS | 331771-20-1 |
| MW: | 513.59 D |
ab 45,00 €
Danusertib
Artikelnummer: TGM-T2094-1mg
Description: Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed. Target: FGFR, Bcr-Abl,...
| Schlagworte: | PHA-739358 |
| Anwendung: | Aurora kinase inhibitor |
| CAS | 827318-97-8 |
| MW: | 474.55 D |
ab 55,00 €
AZD 1152 (hydrochloride)
Artikelnummer: TGM-T36199-10mg
Description: AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of...
| Anwendung: | Aurora kinase B inhibitor prodrug |
| CAS | 722543-50-2 |
| MW: | 660.47 D |
ab 62,00 €
Binucleine 2
Artikelnummer: TGM-T36801-10mg
Description: Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 µM), specifically inhibiting it in a dose-dependent manner while exhibiting minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 µM. At 40 µM, Binucleine 2 induces...
| Anwendung: | Drosophila Aurora B kinase inhibitor |
| CAS | 220088-42-6 |
| MW: | 291.71 D |
ab 88,00 €
Aurora kinase inhibitor-9
Artikelnummer: TGM-T62789-100mg
Description: Aurora kinase inhibitor-9 (compound 9d) is a potent AURKA/B bipolar kinase inhibitor with an IC50 of 0.093 µM for Aurora A and 0.09 µM for Aurora B, demonstrating broad-spectrum anti-proliferative activity. Target: Others. Smiles: N(C=1C2=C(N=CC1C(OCC)=O)C=C(Cl)C=C2Cl)C3=CC(S(NC)(=O)=O)=CC=C3
| Anwendung: | Aurora kinase inhibitor |
| CAS | 2419107-09-6 |
| MW: | 454.33 D |
ab 1.520,00 €