CWHM12

CWHM12 is an analog of RGD peptide (Cay-14501), a tripeptide that inhibits integrin-ligand interactions in studies related to cell adhesion, migration, growth, and differentiation. CWHM12 selectively inhibits alphav integrins (IC50s = 1.8, 0.8, 61, 1.5, and 0.2 nM for alphavbeta1, alphavbeta3, alphavbeta5, alphavbeta6, and alphavbeta8, respectively) over alphaIIbbeta3, alpha2beta1, and alpha10beta1. CWHM 12 attenuates liver, lung, and pancreatic fibrosis in mice treated with CCl4 or cerulein.Formal Name: (3S)-N-[3-hydroxy-5-[(1,4,5,6-tetrahydro-5-hydroxy-2-pyrimidinyl)amino]benzoyl]glycyl-3-[3-bromo-5-(1,1-dimethylethyl)phenyl]-beta-alanine. CAS Number: 1564286-55-0. Molecular Formula: C26H32BrN5O6. Formula Weight: 590.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml. lambdamax: 299 nm. SMILES: OC1=CC(C(NCC(N[C@@H](CC(O)=O)C2=CC(Br)=CC(C(C)(C)C)=C2)=O)=O)=CC(NC3=NCC(O)CN3)=C1. InChi Code: InChI=1S/C26H32BrN5O6/c1-26(2,3)16-4-14(5-17(27)8-16)21(10-23(36)37)32-22(35)13-28-24(38)15-6-18(9-19(33)7-15)31-25-29-11-20(34)12-30-25/h4-9,20-21,33-34H,10-13H2,1-3H3,(H,28,38)(H,32,35)(H,36,37)(H2,29,30,31)/t21-/m0/s1. InChi Key: YDHAGPCZRFQPOI-NRFANRHFSA-N.