Zu "K06487" wurden 135 Artikel gefunden!
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Cyclo(RGDfK) (trifluoroacetate salt)
Artikelnummer: Cay44991-10
An inhibitor of alphavbeta3 integrin (IC50 = 1.33 nM), taken up into tumors in vivo and in vitro, has been polymerized or conjugated to various fluorophores, radiolabels, and peptide sequences for use in fluorescent and PET imaging to study tumor cell adhesion. SMILES:...
| Schlagworte: | Cyclo(Arg-Gly-Asp-D-Phe-Lys), cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-L-lysyl), 2,2,2-trifluoroacetate |
| Anwendung: | Alphavbeta3 integrin inhibitor |
| MW: | 603.68 D |
ab 146,00 €
Anti-Alpha-V/Beta-3 Integrin, Human, mAb BV3
Artikelnummer: HYC-HM2034-100UG
For flow cytometry and immunohistochemistry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
| Schlagworte: | Anti-ITGAV, Anti-Integrin alpha-V, Anti-Vitronectin receptor, Anti-Vitronectin receptor subunit alpha |
| Anwendung: | FC, ELISA, IF, IP, IHC-P |
| Spezies-Reaktivität: | human |
ab 139,00 €
Anti-Recombinant Integrin alphaV, clone 9B6
Artikelnummer: E-AN301281L.100
ITGAV(integrin subunit alpha V) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically...
| Schlagworte: | Anti-ITGAV, Anti-Integrin alpha-V, Anti-Vitronectin receptor, Anti-Vitronectin receptor subunit alpha, Recombinant... |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
GSK3008348
Artikelnummer: Cay43471-1
GSK3008348 is an integrin alphaVbeta6 inhibitor (Ki = 0.01 nM). It is selective for integrin alphaVbeta6 over integrins alphaVbeta1, alphaVbeta3, alphaVbeta5, and alphaVbeta8 (IC50s = 3.9, 50, 1,000, 126, and 16 nM, respectively, in cell adhesion assays). GSK3008348 induces internalization and degradation of...
| Schlagworte: | (betaS,3R)-beta-[3-(3,5-dimethyl-(1H-pyrazol-1-(yl)phenyl]-3-([2-(5,6,7,8-(tetrahydro-(1,8-(naphthyridin-(2-yl)ethyl]-1-py... |
| Anwendung: | Integrin alphaVbeta6 inhibitor |
| CAS | 1629249-33-7 |
| MW: | 487.65 D |
ab 53,00 €
SB-273005
Artikelnummer: Cay34404-5
A nonpeptide alphaVbeta3 and alphaVbeta5 integrin antagonist (Kis =1.2 and 0.3 nM, respectively), reduces paw edema and increases bone density in a rat model of adjuvant-induced arthritis at 30 and 60 mg/kg, reduces the number of Th2 cells and production of IL-10 in pregnant mice at 3 mg/kg. Formulation: A solid....
| Schlagworte: | 2,3,4S,5-tetrahydro-8-[2-[6-(methylamino)-2-pyridinyl]ethoxy]-3-oxo-2-(2,2,2-trifluoroethyl)-1H-2-benzazepine-4-acetic acid |
| Anwendung: | Nonpeptide alphaVbeta3 / alphaVbeta5 integrin antagonist |
| CAS | 205678-31-5 |
| MW: | 451.44 D |
ab 97,00 €
CWHM12
Artikelnummer: Cay19480-5
CWHM12 is an analog of RGD peptide (Cay-14501), a tripeptide that inhibits integrin-ligand interactions in studies related to cell adhesion, migration, growth, and differentiation. CWHM12 selectively inhibits alphav integrins (IC50s = 1.8, 0.8, 61, 1.5, and 0.2 nM for alphavbeta1, alphavbeta3, alphavbeta5,...
| Schlagworte: | (3S)-N-[3-hydroxy-5-[(1,4,5,6-tetrahydro-5-hydroxy-2-pyrimidinyl)amino]benzoyl]glycyl-3-[3-bromo-5-(1,1-dimethylethyl)phen... |
| Anwendung: | Integrin alpha-V inhibitor |
| CAS | 1564286-55-0 |
| MW: | 590.5 D |
ab 56,00 €
Cilengitide
Artikelnummer: Cay22289-10
Cilengitide is a cyclo-(Arg-Gly-Asp-D-Phe-Val) (cRGDfV) peptide and integrin alphaVbeta3 receptor antagonist. It inhibits adhesion and induces apoptosis of U87MG and U373MG malignant glioma (MG) cells, but not U251MG cells that lack the integrin alphaVbeta3 receptor, in vitro at a concentration of 20 µg/ml....
| Schlagworte: | EMD 121974, cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl) |
| Anwendung: | Integrin alphaVbeta3 receptor antagonist |
| CAS | 188968-51-6 |
| MW: | 588.7 D |
ab 50,00 €
GLPG0187
Artikelnummer: Cay21792-5
GLPG0187 is a nonpeptide antagonist of alphanu integrin receptors (IC50s = 1.2-3.7 nM). It inhibits osteoclastogenesis, bone resorption, and angiogenesis in vitro and in vivo in mice, which are all hallmarks of bone marrow invasion in metastatic prostate cancer. GLPG0187 reduces epithelial-mesenchymal transition...
| Schlagworte: | 3-[[2,5-dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)s... |
| Anwendung: | ITGAV antagonist |
| CAS | 1320346-97-1 |
| MW: | 595.7 D |
ab 73,00 €
Arg-Gly-Asp (trifluoroacetate salt)
Artikelnummer: Cay31369-25
Arg-Gly-Asp (RGD) is a synthetic peptide corresponding to the cell adhesion sequence for the integrins alphaVbeta1, alphaVbeta3, alphaVbeta5, alphaVbeta6, alphaVbeta8, alpha8beta1, and alpha5beta1. It is a component of radioligands and peptidomimetics that have been used in the study of integrin expression and...
| Schlagworte: | RGD, L-arginylglycyl-L-aspartic acid |
| Anwendung: | Synthetic integrin cell adhesion sequence peptide |
| CAS | 120103-89-1 |
| MW: | 346.3 D |
ab 110,00 €
Anti-Mouse CD51, PE/Cyanine7 conjugated, clone RMV-7
Artikelnummer: E-AB-F1235UH.25
CD51 is a 140 kD protein, also known as alphaV integrin, vitronectin receptor, and integrin alphaV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins beta1, beta3, beta5...
| Schlagworte: | Anti-Itgav, PE/Cyanine7 Anti-Mouse CD51 Antibody[RMV-7] |
| Anwendung: | FC, FC (membrane) |
| Wirt: | Rat |
| Spezies-Reaktivität: | mouse |
ab 97,00 €
alphavbeta5 Integrin-IN-1
Artikelnummer: Cay39733-1
alphavbeta5 Integrin-IN-1 is an inhibitor of alphaVbeta5 integrin (IC50 = 0.0063 µM). It is selective for alphaVbeta5 over alphaVbeta1, alphaVbeta3, alphaVbeta6, and alphaVbeta8 (IC50s = 2.51, 5.01, 50.1, and 50.1 µM, respectively). alphavbeta5 Integrin-IN-1 inhibits adhesion of alphaVbeta5-expressing K562 cells to...
| Schlagworte: | alphavbeta5 Integrin Inhibitor 1,... |
| Anwendung: | AlphaVbeta5 integrin inhibitor |
| CAS | 2615912-33-7 |
| MW: | 475.5 D |
441,00 €
Anti-CD51 (human), clone P2W7
Artikelnummer: ANC-202-020
Human CD51 is an integrin alpha v chain which can associate with five different integrin beta chains to form various adhesion molecules. The alpha v beta 3 integrin complex binds vitronectin at the RGD sequence and also can bind to fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and...
| Schlagworte: | Anti-MSK8, Anti-CD51, Anti-ITGAV, Anti-Integrin alpha-V, Anti-Integrin alpha-V heavy chain, Anti-Integrin alpha-V light... |
| Anwendung: | FC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
256,00 €