CTP354

CTP354 is a deuterated derivative of the GABAA receptor modulator L-838,417. It binds to the GABAA receptor benzodiazepine binding site in non-alpha1 subunit-containing GABAA receptors. CTP354 has a longer duration of action than L-838,417 in a rat model of neuropathic pain induced by sciatic nerve ligation.Formal Name: 3-(2,5-difluorophenyl)-7-[1,1-di(methyl-d3)ethyl-2,2,2-d3]-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine. CAS Number: 1213669-91-0. Molecular Formula: C19H10D9F2N7O. Formula Weight: 408.5. Purity: >99% (deutereated forms d1-d9). Formulation: (Request formulation change), A solid. Solubility: DMF: 3 mg/ml, DMSO: 3 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): insol. lambdamax: 248 nm. SMILES: CN1C(COC2=NN3C(C4=C(C=CC(F)=C4)F)=NN=C3C=C2C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=NC=N1. InChi Code: InChI=1S/C19H19F2N7O/c1-19(2,3)13-8-15-24-25-17(12-7-11(20)5-6-14(12)21)28(15)26-18(13)29-9-16-22-10-23-27(16)4/h5-8,10H,9H2,1-4H3/i1D3,2D3,3D3. InChi Key: BQDUNOMMYOKHEP-GQALSZNTSA-N.