Zu "K05175" wurden 219 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
NEU
Progabide
Artikelnummer: Cay45568-10
Progabide is a GABA receptor agonist. It selectively binds to the GABAA and GABAB receptors in postmortem rat cortical membranes (IC50s = 35 and 100 µM, respectively) over alpha- and beta-adrenergic, dopamine, serotonin, histamine H1, and muscarinic receptors (IC50s = >100 µM) in radioligand binding assays....
| Schlagworte: | SL 76002, 4-[[(4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]-butanamide |
| Anwendung: | GABA receptor agonist |
| CAS | 62666-20-0 |
| MW: | 334.78 D |
ab 64,00 €
alpha-hydroxy Triazolam-13C2-d4 (CRM)
Artikelnummer: Cay43154-100
alpha-hydroxy Triazolam-13C2-d4 (CRM) (Cay-43154) is intended for use as an internal standard for the quantification of alpha-hydroxy triazolam (Cay-40187, Cay-39390) by GC- or LC-MS. alpha-hydroxy Triazolam is categorized as a benzodiazepine. It is an active metabolite of triazolam (Cay-39683, Cay-22577). It has...
| Schlagworte: | (8-chloro-6-(2-chlorophenyl-3,4,5,6-d4)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl-3a,4-13C2)methanol |
| Anwendung: | Certified reference material, GC-MS, LC-MS internal standard, quantification, GABA-A receptor agonist |
| MW: | 365.2 D |
62,00 €
N-Desmethyladinazolam
Artikelnummer: Cay43383-1
N-Desmethyladinazolam (Cay-43383) is an analytical reference standard categorized as a benzodiazepine. N-Desmethyladinazolam is a metabolite of adinazolam (Cay-30186, Cay-18205). This product is intended for research and forensic applications. Synonyms: Mono-N-Demethyladinazolam NDMAD U-42352. Formal Name:...
| Schlagworte: | Mono-N-Demethyladinazolam, NDMAD, U-42352,... |
| Anwendung: | Analytical reference standard, benzodiazepine |
| CAS | 37115-33-6 |
| MW: | 337.81 D |
ab 164,00 €
Etomidate-d5
Artikelnummer: Cay44952-1
Etomidate-d5 (Cay-44952) is intended for use as an internal standard for the quantification of etomidate (Cay-41826, Cay-21993) by GC- or LC-MS. Etomidate is categorized as an anesthetic. Etomidate has been associated with overdose and death. Formulations containing etomidate have been used as anesthetics. This...
| Schlagworte: | (+)-Etomidate-d5, (R)-Etomidate-d5, d-Etomidate-d5, 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid ethyl-d5 ester |
| Anwendung: | Analytical reference standard, GC-MS, LC-MS internal standard, quantification, anesthetic |
| CAS | 3046414-07-4 |
| MW: | 249.32 D |
312,00 €
TP-003
Artikelnummer: Cay43929-10
TP-003 is a positive allosteric modulator of the GABAA receptor (GABAAR). It potentiates GABA-induced currents in HEK293 cells expressing alpha1beta2gamma2, alpha2beta3gamma2, alpha3beta3gamma2, or alpha5beta2gamma2 subunit-containing GABAARs (EC50s = 20. 10. 3. and 5. nM, respectively). TP-003 (10 mg/kg) increases...
| Schlagworte: | 2',4-difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]pyridin-3-yl]-1,1'-biphenyl]-2-carbonitrile |
| Anwendung: | Positive allosteric GABA(A) receptor modulator |
| CAS | 628690-75-5 |
| MW: | 407.4 D |
ab 137,00 €
SAGE-217
Artikelnummer: Cay31755-1
SAGE-217 is a positive allosteric modulator of GABAA receptors. It potentiates GABA-induced currents in LTK cells expressing alpha4beta2gamma2 subunit-containing GABAA receptors and CHO cells expressing alpha4beta3delta subunit-containing GABAA receptors (EC50s = 375 and 299 nM, respectively). SAGE-217 (0.3-10...
| Schlagworte: | S-812217, SGE 797, 1-[(3alpha,5beta)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-1H-pyrazole-4-carbonitrile, Zuranolone |
| Anwendung: | Positive allosteric GABA(A) receptor modulator |
| CAS | 1632051-40-1 |
| MW: | 409.56 D |
ab 126,00 €
Flumazenil
Artikelnummer: Cay14252-10
Flumazenil is a GABAA receptor antagonist (IC50 = 2 nM in a radioligand binding assay using rat cortical synaptosomes). Flumazenil also acts as a partial agonist of GABAA receptors, decreasing the amplitude of electrically stimulated population spikes in rat hippocampal CA1 pyramidal neurons. It increases the number...
| Schlagworte: | Ro 15-1788, Ro 1722, Ro 41-8157, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic... |
| Anwendung: | Benzodiazepine inhibitor, metabolic studies |
| CAS | 78755-81-4 |
| MW: | 303.3 D |
ab 59,00 €
Avermectin B1a
Artikelnummer: Cay22000-5
Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent that binds to high and low affinity sites on the mammalian GABAA receptor. Binding to the high affinity site activates the receptor to increase chloride influx, while binding to the low affinity site blocks the channel. Avermectin B1a inhibits...
| Schlagworte: | Abamectin B1a, Antibiotic C 076B1a, L-676,863, 5-O-demethyl-avermectin A1a |
| Anwendung: | Anthelmintic agent |
| CAS | 65195-55-3 |
| MW: | 873.1 D |
ab 105,00 €
3alpha,5alpha-THDOC
Artikelnummer: Cay28364-500
3alpha,5alpha-THDOC is a neurosteroid and positive allosteric modulator of GABAA receptors. It inhibits binding of the convulsant t-butylbicyclophosphorothionate (TBPS) and increases binding of the benzodiazepine flunitrazepam to rat synaptosomal membrane preparations in a concentration-dependent manner....
| Schlagworte: | 3alpha,5alpha-Tetrahydrodeoxycorticosterone, 3alpha,5alpha-THDOC, 5alpha,3alpha-THDOC, NSC 113927,... |
| Anwendung: | Neurosteroid, GABA(A) receptor positive allosteric modulator |
| CAS | 567-02-2 |
| MW: | 334.5 D |
ab 65,00 €
Pentylenetetrazole
Artikelnummer: Cay18682-10
Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals. Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures. PTZ has diverse, site-specific effects in the brain....
| Schlagworte: | 1,5-Pentamethylenetetrazole, NSC 5729, NSC 66489, PTZ, alpha,beta-Cyclopentamethylenetetrazole,... |
| Anwendung: | Seizure inducer, GABA(A) receptor antagonist |
| CAS | 54-95-5 |
| MW: | 138.2 D |
69,00 €
Rilmazolam
Artikelnummer: Cay39863-1
Rilmazolam (Cay-39863) is an analytical reference standard categorized as a triazolobenzodiazepine. Rilmazolam is an active metabolite of rilmazafone. This product is intended for research and forensic applications.Formal Name:...
| Schlagworte: | 8-chloro-6-(2-chlorophenyl)-N,N-dimethyl-4H-[1,2,4]triazolo[1,5-a][1,4]benzodiazepine-2-carboxamide |
| Anwendung: | Analytical reference standard, triazolobenzodiazepine |
| CAS | 50330-59-1 |
| MW: | 400.3 D |
ab 197,00 €
Anti-GABRA4
Artikelnummer: A304-386A
Protein function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [The UniProt Consortium]
| Schlagworte: | Anti-GABRA4, Anti-GABA(A) receptor subunit alpha-4, Anti-Gamma-aminobutyric acid receptor subunit alpha-4 |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €