CPTH2 (hydrochloride)

Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. CPTH2 inhibits the HAT activity of Gcn5 both in vitro and in vivo, reducing histone H3K14 acetylation at a concentration of 0.8 mM. It is a useful tool to study the impact of Gcn5-dependent acetylation in various biological systems and recently has been used to control the replication of human adenovirus.Formal Name: 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone, monohydrochloride. CAS Number: 2108899-91-6. Molecular Formula: C14H14ClN3S . HCl. Formula Weight: 328.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 16 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.30 mg/ml, Ethanol: 5 mg/ml. lambdamax: 250, 280 nm. SMILES: ClC(C=C1)=CC=C1C2=CSC(N/N=C3CCCC\3)=N2.Cl. InChi Code: InChI=1S/C14H14ClN3S.ClH/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12,/h5-9H,1-4H2,(H,16,18),1H. InChi Key: ODVWZAKKCNHATB-UHFFFAOYSA-N.