Zu "K06062" wurden 53 Artikel gefunden!
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Gcn5 (human, recombinant)
Artikelnummer: Cay10782-100
Gcn5 and PCAF are highly homologous members of the Gcn5-related N-acetyltransferase (GNAT) superfamily of N-acetyltransferases involved in histone acetylation. Gcn5 and PCAF contain a highly conserved central core with divergent N- and C-terminal ends. Gcn5/PCAF are enzymatic subunits that exist in a mutually...
| Schlagworte: | hGCN5, hGCN5, STAF97, STAF97, Lysine acetyltransferase 2A, Lysine acetyltransferase 2A, Histone acetyltransferase GCN5,... |
| Anwendung: | Enzyme activity |
| MW: | 96,3 kD |
579,00 €
Garcinol
Artikelnummer: Cay10566-5
Garcinol is a polyisoprenylated benzophenone that has been found in G. indica and has diverse biological activities. It inhibits the histone acetyltransferases (HATs) p300 and p300/CREB-binding protein-associated factor (PCAF, IC50s = ~7 and ~5 µM, respectively), as well as COX-1, microsomal prostaglandin E2 (PGE2)...
| Schlagworte: | Camboginol,... |
| Anwendung: | HATs inhibitor |
| CAS | 78824-30-3 |
| MW: | 602.8 D |
ab 77,00 €
CAY10669
Artikelnummer: Cay10974-1
CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor, IC50 = 662 µM), displaying a 2-fold improvement in inhibitory potency over anacardic acid (Cay-13144). At 30-60 µM, CAY10669 can dose-dependently inhibit histone H4 acetylation in HepG2 cells in vitro.Formal...
| Schlagworte: | 2-hydroxy-6-[(1Z)-2-[4-(pentyloxy)phenyl]ethenyl]-benzoic acid |
| Anwendung: | Histone acetyltransferase pCAF inhibitor |
| CAS | 1243583-88-1 |
| MW: | 326.4 D |
ab 109,00 €
CPTH2 (hydrochloride)
Artikelnummer: Cay12086-5
Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. CPTH2 inhibits the HAT activity of Gcn5 both in vitro and in vivo, reducing histone H3K14 acetylation at a concentration of 0.8 mM. It...
| Schlagworte: | 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone, monohydrochloride |
| Anwendung: | HAT inhibitor |
| CAS | 2108899-91-6 |
| MW: | 328.3 D |
ab 130,00 €
Butyrolactone 3
Artikelnummer: Cay12095-1
Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. Butyrolactone 3 specifically inhibits the histone acetyltransferase Gcn5 with an IC50 value of 100 µM and has an affinity to the Gcn5...
| Schlagworte: | rel-tetrahydro-4-methylene-5-oxo-2R-propyl-3S-furancarboxylic acid |
| Anwendung: | HAT inhibitor |
| CAS | 778649-18-6 |
| MW: | 184.2 D |
ab 73,00 €
GCN5 Chemiluminescent Assay Kit
Artikelnummer: BPS-50079L
The GCN5 Chemiluminescent Assay Kit is an enzyme-linked immunosorbent assay (ELISA) designed to screen for inhibitors of GCN5. The GCN5 Chemiluminescent Assay Kit is based on the GCN5 enzyme transferring an acetyl group from an acetyl donor (acetyl CoA) to a histone substrate. The acetylated histone is recognized by...
| Schlagworte: | hGCN5, STAF97, Lysine acetyltransferase 2A, Histone acetyltransferase GCN5, Histone acetyltransferase KAT2A, Histone... |
| Anwendung: | Studying enzyme activity, drug discovery, HTS |
| Spezies-Reaktivität: | human |
686,00 €
Anacardic Acid
Artikelnummer: Cay13144-10
Anacardic acid, isolated from cashew shells or several other medicinal plants, is the general name given to a family of four different 6-alkyl salicyclic acids having varying degrees of unsaturation in the 15-carbon alkyl chain. These compounds are associated with anti-inflammatory, anti-tumor, molluscicidal, and...
| Schlagworte: | 6-pentadecyl Salicylic Acid, 2-hydroxy-6-pentadecyl-benzoic acid |
| Anwendung: | HAT inhibitor |
| CAS | 16611-84-0 |
| MW: | 348.5 D |
ab 35,00 €
GSK4027
Artikelnummer: Cay23421-10
GSK4027 is a p300/CBP-associated factor (PCAF)/general control nonderepressible 5 (GCN5) bromodomain inhibitor (Ki = 1.4 nM, IC50 = 60 nM in a chromatin engagement assay). It is greater than 18,000-fold selective for PCAF and GCN5 over BET family bromodomains and greater than 70-fold selective over other bromodomain...
| Schlagworte: | 4-bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenyl-3-piperidinyl]amino]-3(2H)-pyridazinone |
| Anwendung: | PCAF / GCN5 bromodomain inhibitor |
| CAS | 2079896-25-4 |
| MW: | 377.3 D |
ab 60,00 €
PCAF Histone Acetyltransferase (human, recombinant)
Artikelnummer: Cay10009115-100
p300/(CREB binding protein) associated factor (PCAF) belongs to the GCN5/PCAF family of nuclear histone acetyltransferases (HATs). Gcn5/PCAF proteins contain a ~160 residue HAT domain and a conserved bromodomain directly C-terminal to the HAT domain, which has been shown recently to be an acetyl-lysine targeting...
| Schlagworte: | HAT, p300/(CREB binding protein) Associated Factor |
| Anwendung: | Enzyme activity |
| MW: | 40 kD |
658,00 €
Anti-PCAF
Artikelnummer: A301-666A-T
Protein function: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and...
| Schlagworte: | Anti-PCAF, Anti-P/CAF, Anti-KAT2B, EC=2.3.1.48, Anti-Histone acetylase PCAF, Anti-P300/CBP-associated factor, Anti-Lysine... |
| Anwendung: | WB, IP, ChIP-Seq |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
L-Moses (hydrochloride)
Artikelnummer: Cay21288-1
L-Moses is an inhibitor of the p300/CBP-associated factor (PCAF) bromodomain (Kd = 126 nM). It is selective for PCAF over GCN5 (Kd = 600 nM) and >4,500-fold selective for PCAF over BRD4. L-Moses displaces the PCAF bromodomain from histone H3.3 in a nanoBRET target engagement assay when used at a concentration of 5...
| Schlagworte: | L-45, (1S,2S)-N1,N1-dimethyl-N2-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)-1-phenyl-1,2-propanediamine, dihydrochloride |
| Anwendung: | PCAF bromodomain inhibitor |
| MW: | 433.4 D |
ab 50,00 €
Butyrolactone 3
Artikelnummer: AG-CR1-3522-M002
Specific histone acetyltransferase Gcn5 inhibitor. Anticancer compound. Pre-mRNA splicing inhibitor. Blocks splicing before the first catalytic steps. Potential anti-inflammatory compound.
| Schlagworte: | (2R,3S)-rel-Tetrahydro-4-methylene-5-oxo-2-propyl-3-furancarboxylic acid, MB-3 |
| Anwendung: | Histone acetyltransferase Gcn5 inhibitor |
| CAS | 778649-18-6 |
| MW: | 184 D |
105,00 €