CP 945,598 (hydrochloride)

CP 945,598 (hydrochloride) is a selective antagonist of the cannabinoid receptor CB1 with a Ki value of 0.7 nM and demonstrates relatively low affinity for CB2 receptors (Ki = 7.6 µM). It is reported to reverse cannabinoid agonist-mediated responses (i.e., hypo-locomotion, hypothermia, analgesia, and catalepsy), to reduce food intake, and to increase energy expenditure as well as fat oxidation in rats.Formal Name: 1-[8-(2-chlorophenyl)-9-4-chlorophenyl)-9H-purine-6-yl]-4-ethylamino)-4-piperidinecarboxamide, monohydrochloride. CAS Number: 686347-12-6. Synonyms: Otenabant. Molecular Formula: C25H25Cl2N7O . HCl. Formula Weight: 546.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.30 mg/ml. lambdamax: 281 nm. SMILES: ClC(C=CC=C1)=C1C2=NC3=C(N4CCC(NCC)(C(N)=O)CC4)N=CN=C3N2C5=CC=C(Cl)C=C5.Cl. InChi Code: InChI=1S/C25H25Cl2N7O.ClH/c1-2-31-25(24(28)35)11-13-33(14-12-25)22-20-23(30-15-29-22)34(17-9-7-16(26)8-10-17)21(32-20)18-5-3-4-6-19(18)27,/h3-10,15,31H,2,11-14H2,1H3,(H2,28,35),1H. InChi Key: KPYUQCJBZGQHPL-UHFFFAOYSA-N.