CGS 15943

CGS 15943 is an orally bioavailable non-xanthine antagonist at adenosine (A) receptors with IC50 values of 3.5, 4.2, 16, and 51 nM in CHO cells transfected with human recombinant A1, A2A, A2B, and A3 receptors, respectively. It also binds to the phosphatidylinositol 3-kinase (PI3K) catalytic subunit p110gamma, and it inhibits proliferation of HCC hepatocellular carcinoma and PDAC pancreatic cancer adenocarcinoma cells through the PI3K/Akt signaling pathway. In rats, CGS 15943 (0.1-10 mg/kg, i.p.) increases locomotor activity in a dose-dependent manner. It also reinforces and reinstates cocaine-seeking in baboons through an adenosine-dependent mechanism.Formal Name: 9-chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine. CAS Number: 104615-18-1. Synonyms: CGS 15943A. Molecular Formula: C13H8ClN5O. Formula Weight: 285.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 0.5 mg/ml. lambdamax: 260 nm. SMILES: ClC1=CC=C(C2=C1)N=C(N)N3C2=NC(C4=CC=CO4)=N3. InChi Code: InChI=1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16). InChi Key: MSJODEOZODDVGW-UHFFFAOYSA-N.