CGP 77675 (hydrate)

CGP 77675 is an inhibitor of Src family kinases (SFKs) that blocks the phosphorylation of peptide substrates and autophosphorylation of purified c-Src (IC50s = 5-20 and 40 nM, respectively). It also inhibits the SFKs Lck and c-Yes with low nanomolar IC50 values. CGP 77675 is used to elucidate the role of SFKs in such processes as bone resorption, tight junction formation in epithelial cells, and allograft survival. It can also be used in combination with the GSK3 inhibitor CHIR99021 (Cay-13122) to maintain mouse embryonic stem cells.Formal Name: 1-[2-[4-[4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]ethyl]-4-piperidinol, hydrate. Molecular Formula: C26H29N5O2 . XH2O. Formula Weight: 443.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml. lambdamax: 246, 291 nm. SMILES: OC1CCN(CCC2=CC=C(N3C4=NC=NC(N)=C4C(C5=CC=CC(OC)=C5)=C3)C=C2)CC1.O. InChi Code: InChI=1S/C26H29N5O2.H2O/c1-33-22-4-2-3-19(15-22)23-16-31(26-24(23)25(27)28-17-29-26)20-7-5-18(6-8-20)9-12-30-13-10-21(32)11-14-30,/h2-8,15-17,21,32H,9-14H2,1H3,(H2,27,28,29),1H2. InChi Key: LSXWPUKDLIQZLP-UHFFFAOYSA-N.