Zu "K05704" wurden 181 Artikel gefunden!
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1-NA-PP1
Artikelnummer: Cay10954-10
1-NA-PP1 is a reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. 1-NA-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over...
| Schlagworte: | 1-Naphthyl-PP1, PP1 Analog, 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| CAS | 221243-82-9 |
| MW: | 317.4 D |
ab 36,00 €
Anti-Recombinant Src, clone 4B3
Artikelnummer: E-AN300804L.100
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene...
| Schlagworte: | Anti-SRC, Anti-pp60c-src, Anti-Proto-oncogene c-Src, Anti-Proto-oncogene tyrosine-protein kinase Src, Recombinant Src... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-phospho-Src (Tyr529), clone 32S01
Artikelnummer: NSJ-FY12031
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-Src (Tyr529) antibody detects Src kinase phosphorylated at tyrosine 529, a regulatory modification that maintains Src in an inactive conformation. Src is a non-receptor tyrosine kinase involved...
| Schlagworte: | Anti-phospho-SRC, Anti-phospho-pp60c-src, Anti-phospho-Proto-oncogene c-Src, Anti-phospho-Proto-oncogene tyrosine-protein... |
| Anwendung: | WB, ICC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
K882
Artikelnummer: Cay43422-1
An inhibitor of Src kinase, binds to Src (Kd = 315 nM), decreases phosphorylation at the Y416 activation site, and increases phosphorylation at the Y527 inactivation site, reduces the proliferation of wild-type NCI H358 cells and KRASG12C-expressing NCI H358 cells (IC50s = 2.14 and 2.03 µM, respectively), inhibits...
| Schlagworte: | (E)-4-(2,5-dimethoxystyryl)quinazoline |
| Anwendung: | Src inhibitor |
| MW: | 292.34 D |
ab 49,00 €
Bosutinib
Artikelnummer: Cay12030-5
Bosutinib is an inhibitor of c-Src and Abl kinases (IC50s = 1.2 and 1 nM, respectively). It also inhibits the kinases EPHB2, TrkA, TrkB, and TXK (IC50s = 8.5, 22, 27, and 40 nM, respectively) among others. Bosutinib inhibits Src-dependent cell proliferation (IC50 = 100 nM) and reverses Src-transformed fibroblasts to...
| Schlagworte: | SKI 606, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile |
| Anwendung: | c-Src and Abl inhibitor |
| CAS | 380843-75-4 |
| MW: | 530.5 D |
ab 67,00 €
Dasatinib
Artikelnummer: Cay11498-50
Dasatinib is a potent inhibitor of the non-receptor tyrosine kinases Abl and Src as well as other members of the Src family. It is effective at sub-nanomolar concentrations, inhibiting Src, Abl, and Lck with IC50 values of 0.05, 0.5, and 0.4 nM, respectively. At nanomolar concentrations, dasatinib also blocks the...
| Schlagworte: | BMS 354825, Sprycel,... |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 302962-49-8 |
| MW: | 488 D |
ab 49,00 €
SU6656
Artikelnummer: Cay13338-5
The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). It weakly...
| Schlagworte: | 2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide |
| Anwendung: | Src kinase inhibitor |
| CAS | 330161-87-0 |
| MW: | 371.5 D |
ab 38,00 €
Altenusin
Artikelnummer: Cay26911-1
Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities. It inhibits Src kinase with an IC50 value of 20 nM. Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human...
| Schlagworte: | Alutenusin, 3,4',5'-trihydroxy-5-methoxy-2'-methyl-[1,1'-biphenyl]-2-carboxylic acid |
| Anwendung: | Bioactive polyphenol fungal metabolite, Src inhibitor |
| CAS | 31186-12-6 |
| MW: | 290.3 D |
ab 111,00 €
SRC (GST-tag), active human recombinant protein
Artikelnummer: BPS-40483
Active human SRC (GenBank Accession No. NM_005417), full length with N-terminal GST tag, MW = 86 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | SRC1, p60-Src, pp60c-src, Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 86 kD |
536,00 €
PP3
Artikelnummer: Cay15595-1
The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. Several small molecule...
| Schlagworte: | NSC 1401, 1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Anwendung: | Inactive Src tyrosine kinase inhibitor analog |
| CAS | 5334-30-5 |
| MW: | 211.2 D |
ab 85,00 €
KX2-391
Artikelnummer: Cay21429-5
KX2-391 is an inhibitor of Src kinase (IC50 = ~20 nM). It is selective for Src over PDGFR, EGFR, JAK1, JAK2, Lck, and ZAP-70. KX2-391 induces cell cycle arrest at the G2/M phase and apoptosis in breast cancer cells expressing estrogen receptor alpha (ERalpha). It inhibits the growth of Huh7, PLC/PRF/5, Hep3B, and...
| Schlagworte: | KX 01, 5-[4-[2-(4-morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-2-pyridineacetamide |
| Anwendung: | Src kinase inhibitor |
| CAS | 897016-82-9 |
| MW: | 431.5 D |
ab 81,00 €
PP1
Artikelnummer: AG-CR1-3562-M005
Highly potent and selective Scr family tyrosine kinase inhibitor. Shows anti-Ras cancer potential by blocking Ras-induced activation of PAK1. Antitumor compound. RIP2 inhibitor. Blocks TGF-beta-mediated cellular responses.
| Schlagworte: | 4-Amino-5-(methylphenyl)-7-(tert.butyl)pyrazolo-(3,4-d)pyrimidine |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 172889-26-8 |
| MW: | 281,4 D |
ab 44,00 €