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Zu "K05704" wurden 163 Artikel gefunden!
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Artikelnummer: Cay10954-10
1-NA-PP1 is a reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. 1-NA-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over...
Schlagworte: | 1-Naphthyl-PP1, PP1 Analog, 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
CAS | 221243-82-9 |
MW: | 317.4 D |
ab 31,00 €
Artikelnummer: NSJ-RQ5396
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The SRC gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose...
Schlagworte: | Anti-SRC1, Anti-p60-Src, Anti-pp60c-src, Anti-Proto-oncogene c-Src, Anti-Proto-oncogene tyrosine-protein kinase Src, Src... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
755,00 €
Artikelnummer: NSJ-RQ5397
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The SRC gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose...
Schlagworte: | Anti-SRC1, Anti-p60-Src, Anti-pp60c-src, Anti-Proto-oncogene c-Src, Anti-Proto-oncogene tyrosine-protein kinase Src, Src... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
755,00 €
Artikelnummer: Cay21089-10
CGP 77675 is an inhibitor of Src family kinases (SFKs) that blocks the phosphorylation of peptide substrates and autophosphorylation of purified c-Src (IC50s = 5-20 and 40 nM, respectively). It also inhibits the SFKs Lck and c-Yes with low nanomolar IC50 values. CGP 77675 is used to elucidate the role of SFKs in...
Schlagworte: | 1-[2-[4-[4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]ethyl]-4-piperidinol |
Anwendung: | Src inhibitor |
MW: | 443.5 D |
ab 52,00 €
Artikelnummer: Cay12030-5
Bosutinib is an inhibitor of c-Src and Abl kinases (IC50s = 1.2 and 1 nM, respectively). It also inhibits the kinases EPHB2, TrkA, TrkB, and TXK (IC50s = 8.5, 22, 27, and 40 nM, respectively) among others. Bosutinib inhibits Src-dependent cell proliferation (IC50 = 100 nM) and reverses Src-transformed fibroblasts to...
Schlagworte: | SKI 606, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile |
Anwendung: | c-Src and Abl inhibitor |
CAS | 380843-75-4 |
MW: | 530.5 D |
ab 60,00 €
Artikelnummer: Cay11498-50
Dasatinib is a potent inhibitor of the non-receptor tyrosine kinases Abl and Src as well as other members of the Src family. It is effective at sub-nanomolar concentrations, inhibiting Src, Abl, and Lck with IC50 values of 0.05, 0.5, and 0.4 nM, respectively. At nanomolar concentrations, dasatinib also blocks the...
Schlagworte: | BMS 354825, Sprycel,... |
Anwendung: | Tyrosine kinase inhibitor |
CAS | 302962-49-8 |
MW: | 488 D |
ab 43,00 €
Artikelnummer: Cay13338-5
The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). It weakly...
Schlagworte: | 2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide |
Anwendung: | Src kinase inhibitor |
CAS | 330161-87-0 |
MW: | 371.5 D |
ab 32,00 €
Artikelnummer: Cay26911-1
Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities. It inhibits Src kinase with an IC50 value of 20 nM. Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human...
Schlagworte: | Alutenusin, 3,4',5'-trihydroxy-5-methoxy-2'-methyl-[1,1'-biphenyl]-2-carboxylic acid |
Anwendung: | Bioactive polyphenol fungal metabolite, Src inhibitor |
CAS | 31186-12-6 |
MW: | 290.3 D |
ab 100,00 €
Artikelnummer: BPS-40483
Active human SRC (GenBank Accession No. NM_005417), full length with N-terminal GST tag, MW = 86 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Schlagworte: | SRC1, p60-Src, pp60c-src, Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src, |
Anwendung: | Enzyme kinetics, inhibitor screening |
MW: | 86 kD |
525,00 €
Artikelnummer: Cay15595-1
The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. Several small molecule...
Schlagworte: | NSC 1401, 1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
Anwendung: | Inactive Src tyrosine kinase inhibitor analog |
CAS | 5334-30-5 |
MW: | 211.2 D |
ab 77,00 €
Artikelnummer: Cay21429-5
KX2-391 is an inhibitor of Src kinase (IC50 = ~20 nM). It is selective for Src over PDGFR, EGFR, JAK1, JAK2, Lck, and ZAP-70. KX2-391 induces cell cycle arrest at the G2/M phase and apoptosis in breast cancer cells expressing estrogen receptor alpha (ERalpha). It inhibits the growth of Huh7, PLC/PRF/5, Hep3B, and...
Schlagworte: | KX 01, 5-[4-[2-(4-morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-2-pyridineacetamide |
Anwendung: | Src kinase inhibitor |
CAS | 897016-82-9 |
MW: | 431.5 D |
ab 130,00 €
Artikelnummer: 0080-100
Does not cross-react with the non-phosphorylated form of src or with unrelated phosphorylation sites.
Schlagworte: | (pY416) EC=2.7.10.2, Anti-phospho-SRC, Anti-phospho-SRC1, Anti-phospho-p60-Src, Anti-phospho-pp60c-src,... |
Anwendung: | WB, ELISA, ICC, FC |
Wirt: | Mouse |
Spezies-Reaktivität: | human, mouse |
383,00 €