Cdk2 Inhibitor II

The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G2-M transition during the cell cycle. Cdk2 Inhibitor II is a 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 (IC50 = 60 nM). It is cell permeable, reversible, and ATP-competitive.Formal Name: 4-[2-(5-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazinyl]-benzenesulfonamide. CAS Number: 222035-13-4. Synonyms: Cyclin-dependent kinase 2 Inhibitor II, SC-221409. Molecular Formula: C14H11BrN4O3S. Formula Weight: 395.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml. lambdamax: 213, 257, 395 nm. SMILES: BrC1=CC=C(NC(/C2=N\NC3=CC=C(S(N)(=O)=O)C=C3)=O)C2=C1. InChi Code: InChI=1S/C14H11BrN4O3S/c15-8-1-6-12-11(7-8)13(14(20)17-12)19-18-9-2-4-10(5-3-9)23(16,21)22/h1-7,18H,(H2,16,21,22)(H,17,19,20). InChi Key: ODZNNZYRBRRREX-UHFFFAOYSA-N.