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Zu "K02206" wurden 131 Artikel gefunden!
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Artikelnummer: Cay39153-1
CK7 is an inhibitor of cyclin-dependent kinase 2 (Cdk2) and Cdk9 (Kis = 2 and 4 nM, respectively). It is selective for Cdk2 and Cdk9 over Cdk1, Cdk4, and Cdk7 (Kis = 80, 53, and 70 nM, respectively), as well as 10 additional kinases (Kis = >1,000 nM for all). CK7 is cytotoxic to A2780 ovarian and MES-SA uterine...
Schlagworte: | Cdk2/9 Inhibitor, Cyclin-dependent kinase 2/9 Inhibitor, 4-(2-amino-4-methyl-5-thiazolyl)-N-(3-nitrophenyl)-2-pyrimidinamine |
Anwendung: | Cdk2/Cdk9 inhibitor |
CAS | 507487-89-0 |
MW: | 328.4 D |
ab 93,00 €
-10 %
Rabattaktion
Artikelnummer: ELK-ELK2254.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CDK2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CDK2. Next,...
Schlagworte: | CDK2, CDKN2, p33 protein kinase, Cyclin-dependent kinase 2, Cell division protein kinase 2 |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
365,00 €
ab 328,50 €
Artikelnummer: Cay38526-25
AZD 5597 is a cyclin-dependent kinase 1 (Cdk1) and Cdk2 inhibitor (IC50 = 0.002 µM for both). It inhibits LoVo cell proliferation (IC50 = 0.039 µM). In vivo, AZD 5597 (15 mg/kg) reduces tumor volume in an SW620 colon adenocarcinoma mouse xenograft model.Formal Name:...
Schlagworte: | [4-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-2-pyrimidinyl]amino]phenyl][(3S)-3-(methylamino)-1-pyrrolidi... |
Anwendung: | Cdk1 / Cdk2 inhibitor |
CAS | 924641-59-8 |
MW: | 437.5 D |
ab 158,00 €
Artikelnummer: Cay14428-1
Alsterpaullone is a derivative of kenpaullone (Cay-10010239), an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3beta (GSK3beta). With slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E,...
Schlagworte: | 9-Nitropaullone, NSC 705701, 7,12-dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one |
Anwendung: | CDK inhibitor, GSK-3beta inhibitor |
CAS | 237430-03-4 |
MW: | 293.3 D |
ab 92,00 €
Artikelnummer: Cay35502-1
PF-06873600 is an inhibitor of cyclin-dependent kinase 2 (Cdk2), Cdk4, and Cdk6 (Kis = 0.13, 1.25, and 0.11 nM, respectively). It is selective for these CDKs over Cdk1 and Cdk9 (Kis = 4.5 and 19.6 nM, respectively). PF-06873600 inhibits the phosphorylation of RB transcriptional corepressor 1 (RB1) in, and the...
Schlagworte: | PF-3600,... |
Anwendung: | Cdk2 inhibitor |
CAS | 2185857-97-8 |
MW: | 471.5 D |
ab 110,00 €
Artikelnummer: A301-812A
Protein function: Serine/threonine-protein kinase involved in the control of the cell cycle, essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F...
Schlagworte: | Anti-CDK2, Anti-CDKN2, Anti-p33 protein kinase, Anti-Cyclin-dependent kinase 2, Anti-Cell division protein kinase 2 |
Anwendung: | WB, IP, IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse |
ab 164,00 €
Artikelnummer: Cay19115-10
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Purvalanol B is a CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively). It is inactive against...
Schlagworte: | NG 95, 2-chloro-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]-benzoic acid |
Anwendung: | CDK inhibitor |
CAS | 212844-54-7 |
MW: | 432.9 D |
ab 56,00 €
Artikelnummer: Cay19168-5
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. BMS-265246 is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin E (IC50s = 6 and 9 nM, respectively). It less potently inhibits Cdk4/cyclin D (IC50 = 0.23 µM). BMS-265246...
Schlagworte: | (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone |
Anwendung: | Cell-permeable Cdk1/cyclin B & Cdk2/cyclin E inhibitor |
CAS | 582315-72-8 |
MW: | 345.3 D |
ab 84,00 €
Artikelnummer: Cay14006-10
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-CR8 is a second-generation analog of (R)-roscovitine (Cay-10009569) that inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T with IC50 values of 0.09,...
Schlagworte: | 2R-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol |
Anwendung: | CDK Inhibitor |
CAS | 294646-77-8 |
MW: | 431.5 D |
ab 77,00 €
Artikelnummer: Cay14796-1
SU 9516 is a 3-substituted indolinone that has anti-proliferative and pro-apoptotic activity in tumor cells. It is a potent inhibitor of several cyclin-dependent kinases (CDKs) with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1). It does not inhibit PKC, p38,...
Schlagworte: | 1,3-dihydro-3Z-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one |
Anwendung: | CDK inhibitor |
CAS | 377090-84-1 |
MW: | 241.3 D |
ab 43,00 €
Artikelnummer: Cay15154-5
The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G2-M transition during the cell cycle. Cdk2 Inhibitor II is a 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 (IC50 = 60 nM). It is cell permeable, reversible, and ATP-competitive.Formal Name:...
Schlagworte: | Cyclin-dependent kinase 2 Inhibitor II, SC-221409,... |
Anwendung: | Cdk2 inhibitor |
CAS | 222035-13-4 |
MW: | 395.2 D |
ab 43,00 €
Artikelnummer: Cay21424-1
Aminopurvalanol A is a selective, cell-permeable, and competitive cyclin-dependent kinase (CDK) inhibitor that potently inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35 (IC50s = 33, 33, 28, and 20 nM, respectively). It is over 90-fold selective for CDKs over ERK1, ERK2, PKC-delta, protein kinase A...
Schlagworte: | NG 97, (2R)-2-[[6-[(3-amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
Anwendung: | Cdk inhibitor |
CAS | 220792-57-4 |
MW: | 403.9 D |
ab 77,00 €