CAY10744

CAY10744 is a topoisomerase II-alpha poison. It inhibits topoisomerase II-alpha by 78.9% when used at a concentration of 20 µM. CAY10744 is selective for topoisomerase II-alpha over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 µM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 µM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 µM. CAY10744 (12 mg/kg per day) reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer.Formal Name: 2-(2-chlorophenyl)-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-6-ol. CAS Number: 2375613-31-1. Molecular Formula: C24H16ClNO2. Formula Weight: 385.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20mg/mL, DMF:PBS (pH 7.2) (1:2): 0.3mg/mL, DMSO: 5mg/mL, Ethanol: 12mg/mL. lambdamax: 266, 301 nm. SMILES: OC1=CC=CC2=C1CC3=C2N=C(C4=C(Cl)C=CC=C4)C=C3C5=CC=C(O)C=C5. InChi Code: InChI=1S/C24H16ClNO2/c25-21-6-2-1-4-17(21)22-13-18(14-8-10-15(27)11-9-14)20-12-19-16(24(20)26-22)5-3-7-23(19)28/h1-11,13,27-28H,12H2. InChi Key: FEGFONFVHVRWGK-UHFFFAOYSA-N.