Zu "K03164" wurden 166 Artikel gefunden!
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Doxorubicin (hydrochloride)
Artikelnummer: Cay15007-5
Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.Formal Name:...
| Schlagworte: | DOX,... |
| Anwendung: | DNA topoisomerase II inhibitor, Antitumor agent |
| CAS | 25316-40-9 |
| MW: | 580 D |
ab 43,00 €
Etoposide
Artikelnummer: Cay12092-25
Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 µM). It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 µM). It reduces tumor growth in an Ma human embryonal carcinoma mouse...
| Schlagworte: | EPE, NSC 141540, VP-16-123,... |
| Anwendung: | DNA Topoisomerase II inhibitor, Apoptosis inducer |
| CAS | 33419-42-0 |
| MW: | 588.6 D |
ab 27,00 €
Anti-Topo II Alpha
Artikelnummer: A300-054A-T
Topoisomerases regulate topological states of DNA and are divided into type I and type II enzymes. Type II topoisomerases make double stranded breaks in DNA and allow the passage of another duplex DNA across the break to achieve unknotting of entangled DNA. Topo II Alpha is one of two described isoforms that are...
| Schlagworte: | Anti-TOP2, Anti-TOP2A, Anti-DNA topoisomerase 2-alpha, Anti-DNA topoisomerase II, alpha isozyme |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
164,00 €
Anti-Topoisomerase II alpha / TOP2A
Artikelnummer: NSJ-RQ5605
0.5mg/ml if reconstituted with 0.2ml sterile DI water. The human topoisomerase II enzyme is encoded by a single-copy gene which is mapped to 17q21-q22. The TOP2A gene spans approximately 30 kb and contains 35 exons. Furthermore, DNA topoisomerases are enzymes that control and alter the topologic states of DNA in...
| Schlagworte: | Anti-TOP2, Anti-TOP2A, Anti-DNA topoisomerase 2-alpha, Anti-DNA topoisomerase II, alpha isozyme, Topoisomerase II alpha... |
| Anwendung: | WB, IHC (paraffin), IF/ICC, FC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
755,00 €
Anti-Topoisomerase II alpha / TOP2A
Artikelnummer: NSJ-F55028-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. TOP2A encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during...
| Schlagworte: | Anti-TOP2, Anti-TOP2A, Anti-DNA topoisomerase 2-alpha, Anti-DNA topoisomerase II, alpha isozyme, Topoisomerase II alpha... |
| Anwendung: | IF, IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 326,00 €
Human TOP2b (Topoisomerase II Beta) ELISA Kit
Artikelnummer: ELK-ELK3315.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TOP2b. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TOP2b. Next,...
| Schlagworte: | TOP2B, DNA topoisomerase 2-beta, DNA topoisomerase II, beta isozyme |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Human TOP2 (Topoisomerase II) ELISA Kit
Artikelnummer: ELK-ELK4023.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TOP2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TOP2. Next,...
| Schlagworte: | TOP2, TOP2A, DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Rat TOP2 (Topoisomerase II) ELISA Kit
Artikelnummer: ELK-ELK4458.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat TOP2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat TOP2. Next,...
| Schlagworte: | Top-2, Top2a, DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | rat |
ab 365,00 €
Mouse TOP2 (Topoisomerase II) ELISA Kit
Artikelnummer: ELK-ELK4460.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TOP2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TOP2. Next,...
| Schlagworte: | Top-2, Top2a, DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Mitoxantrone-d8
Artikelnummer: Cay29414-1
Mitoxantrone-d8 is intended for use as an internal standard for the quantification of mitoxantrone (Cay-14842) by GC- or LC-MS. Mitoxantrone is an inhibitor of DNA topoisomerase IIalpha and HIV-1 integrase (IC50s = 5.3 and 3.8 µM, respectively). It intercalates into DNA in a cell-free assay when used at a...
| Schlagworte: | 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl-1,1,2,2-d4)amino]ethyl]amino]-9,10-anthracenedione |
| Anwendung: | GC-MS, LC-MS, Internal standard, Topoisomerase II inhibitor, HIV-1 integrase inhibitor |
| CAS | 1189974-82-0 |
| MW: | 452.5 D |
406,00 €
Quarfloxin
Artikelnummer: Cay36552-1
Quarfloxin is an inhibitor of RNA polymerase I-mediated transcription. It binds to G-quadruplex DNA and inhibits the interaction between ribosomal DNA G-quadruplexes and nucleolin, a nucleolar protein required for RNA polymerase I-mediated transcription. Quarfloxin (10 µM) induces nucleolin mislocalization from the...
| Schlagworte: | CX-3543, Itarnafloxin, Quarfloxacin,... |
| Anwendung: | RNA polymerase I-mediated transcription inhibitor, antineoplastic, topoisomerase II inhibitor |
| CAS | 865311-47-3 |
| MW: | 604.7 D |
ab 82,00 €
Mitoxantrone (hydrochloride)
Artikelnummer: Cay14842-10
Mitoxantrone is an inhibitor of DNA topoisomerase IIalpha and HIV-1 integrase (IC50s = 5.3 and 3.8 µM, respectively). It intercalates into DNA in a cell-free assay when used at a concentration of 2 µM, as well as inhibits DNA synthesis and induces DNA-protein crosslinks in vitro in a concentration-dependent manner....
| Schlagworte: | NCI 301739, NSC 301739, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione, dihydrochloride |
| Anwendung: | Topoisomerase II inhibitor, HIV-1 integrase inhibitor |
| CAS | 70476-82-3 |
| MW: | 517.4 D |
ab 43,00 €