Zu "K03164" wurden 283 Artikel gefunden!
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Doxorubicin (hydrochloride)
Artikelnummer: Cay15007-5
Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.Formal Name:...
| Schlagworte: | DOX,... |
| Anwendung: | DNA topoisomerase II inhibitor, antitumor agent |
| CAS | 25316-40-9 |
| MW: | 580 D |
ab 60,00 €
NEU
Anti-Human TOP2B Antibody Pair
Artikelnummer: ABS-ES-533.1
Product Description: DNA topoisomerase 2-beta (TOP2B) is a type II topoisomerase that plays a critical role in managing DNA topology during transcription, replication, and chromosome segregation. It functions by creating transient double-strand breaks in DNA, allowing the strands to pass through each other, which...
| Schlagworte: | Anti-TOP2B, Anti-DNA topoisomerase 2-beta, Anti-DNA topoisomerase II, beta isozyme, Human TOP2B Antibody Pair |
| Anwendung: | ELISA |
| Wirt: | Mouse/Mouse |
| Spezies-Reaktivität: | human |
1.080,00 €
NEU
Anti-Human TOP2B Antibody Pair
Artikelnummer: ABS-ES-534.1
Product Description: DNA topoisomerase 2-beta (TOP2B) is a type II topoisomerase that plays a critical role in managing DNA topology during transcription, replication, and chromosome segregation. It functions by creating transient double-strand breaks in DNA, allowing the strands to pass through each other, which...
| Schlagworte: | Anti-TOP2B, Anti-DNA topoisomerase 2-beta, Anti-DNA topoisomerase II, beta isozyme, Human TOP2B Antibody Pair |
| Anwendung: | ELISA |
| Wirt: | Mouse/Mouse |
| Spezies-Reaktivität: | human |
1.080,00 €
NEU
Anti-Human TOP2B Antibody Pair
Artikelnummer: ABS-ES-535.1
Product Description: DNA topoisomerase 2-beta (TOP2B) is a type II topoisomerase that plays a critical role in managing DNA topology during transcription, replication, and chromosome segregation. It functions by creating transient double-strand breaks in DNA, allowing the strands to pass through each other, which...
| Schlagworte: | Anti-TOP2B, Anti-DNA topoisomerase 2-beta, Anti-DNA topoisomerase II, beta isozyme, Human TOP2B Antibody Pair |
| Anwendung: | ELISA |
| Wirt: | Mouse/Mouse |
| Spezies-Reaktivität: | human |
1.080,00 €
Etoposide
Artikelnummer: Cay12092-25
Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 µM). It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 µM). It reduces tumor growth in an Ma human embryonal carcinoma mouse...
| Schlagworte: | EPE, NSC 141540, VP-16-123,... |
| Anwendung: | DNA Topoisomerase II inhibitor, Apoptosis inducer |
| CAS | 33419-42-0 |
| MW: | 588.6 D |
ab 40,00 €
Anti-Topoisomerase II alpha / TOP2A, clone MSVA-802R
Artikelnummer: NSJ-V6123-100UG
Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. DNA topoisomerase II alpha (TOP2A) is a nuclear enzyme that regulates DNA topology during replication, transcription, and chromosome segregation. The protein belongs to the type II DNA topoisomerase family and functions by creating transient double strand breaks...
| Schlagworte: | Anti-TOP2A, Anti-DNA topoisomerase 2-alpha, Anti-DNA topoisomerase II, alpha isozyme, Topoisomerase II alpha Antibody / TOP2A |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 684,00 €
Razoxane
Artikelnummer: Cay45123-10
A racemic mixture of dexrazoxane and levrazoxane, inhibits TOP2A and TOP2B only weakly (IC50s = 301 and 505 µM, respectively), slows tumor growth, normalizes vasculature, and prevents metastases in murine Lewis lung carcinoma models at 30 mg/kg. SMILES: O=C1NC(CN(CC(C)N2CC(NC(C2)=O)=O)C1)=O. InChi Code:...
| Schlagworte: | ICI 59118, ICRF 159, NSC 129943, 4,4'-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione |
| Anwendung: | Weak TOP2A / TOP2B inhibitor |
| CAS | 21416-67-1 |
| MW: | 268.27 D |
ab 89,00 €
Mitoxantrone (hydrochloride)
Artikelnummer: Cay14842-10
Mitoxantrone is an inhibitor of DNA topoisomerase IIalpha and HIV-1 integrase (IC50s = 5.3 and 3.8 µM, respectively). It intercalates into DNA in a cell-free assay when used at a concentration of 2 µM, as well as inhibits DNA synthesis and induces DNA-protein crosslinks in vitro in a concentration-dependent manner....
| Schlagworte: | NCI 301739, NSC 301739, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione, dihydrochloride |
| Anwendung: | Topoisomerase II inhibitor, HIV-1 integrase inhibitor |
| CAS | 70476-82-3 |
| MW: | 517.4 D |
ab 51,00 €
Etoposide
Artikelnummer: AG-CR1-3572-M025
Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a...
| Schlagworte: | VP-16-213, NSC 141540 |
| Anwendung: | Apoptosis Inducer |
| Wirt: | Semisynthetic |
| CAS | 33419-42-0 |
| MW: | 588,6 D |
ab 33,00 €
Daunorubicin (hydrochloride)
Artikelnummer: Cay14159-10
Daunorubicin is an antitumor antibiotic. At 0.2-1µM, daunorubicin induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia (AML) cells. However, immature AML cells (CD 34+-KG1a, -KG1, or -HEL cells) appear resistant to apoptosis at similar concentrations. In mature AML cells,...
| Schlagworte: | NDC 0082-4155, Ondena, RP 13057,... |
| Anwendung: | Antineoplastic, topoisomerase II inhibitor |
| CAS | 23541-50-6 |
| MW: | 564 D |
ab 80,00 €
Anti-Topo II Alpha
Artikelnummer: A300-054A
Protein function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1...
| Schlagworte: | Anti-TOP2, Anti-TOP2A, EC=5.99.1.3, Anti-DNA topoisomerase 2-alpha, Anti-DNA topoisomerase II, alpha isozyme |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
586,00 €
Anti-Topo II Beta
Artikelnummer: A300-949A
Protein function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. [The UniProt Consortium]
| Schlagworte: | Anti-TOP2B, EC=5.99.1.3, Anti-DNA topoisomerase 2-beta, Anti-DNA topoisomerase II, beta isozyme |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €