CAY10684

Prostaglandin E2 (PGE2, Cay-14010) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a G protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10684 is a lactam that acts as a potent EP4 agonist, triggering cAMP signaling with an EC50 value of 0.8 nM. It displays more than 1,000-fold selectivity for EP4 over other EP receptors.Formal Name: (2R)-2-[(1E)-3-(4'-chloro-2'-methyl[1,1'-biphenyl]-3-yl)-3-hydroxy-1-propen-1-yl]-5-oxo-1-pyrrolidineheptanoic acid. CAS Number: 493035-81-7. Molecular Formula: C27H32ClNO4. Formula Weight: 470.0. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 30 mg/mL, DMSO: 17 mg/mL, Ethanol: 50 mg/mL, PBS (pH 7.2): 3 mg/mL. lambdamax: 241 nm. SMILES: O=C1N(CCCCCCC(O)=O)[C@@H](/C=C/C(O)C2=CC(C(C=C3)=C(C)C=C3Cl)=CC=C2)CC1. InChi Code: InChI=1S/C27H32ClNO4/c1-19-17-22(28)10-13-24(19)20-7-6-8-21(18-20)25(30)14-11-23-12-15-26(31)29(23)16-5-3-2-4-9-27(32)33/h6-8,10-11,13-14,17-18,23,25,30H,2-5,9,12,15-16H2,1H3,(H,32,33)/b14-11+/t23-,25?/m0/s1. InChi Key: LMJHPADNCZPRCN-KSPGTVSPSA-N.