Zu "K04261" wurden 35 Artikel gefunden!
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L-902,688
Artikelnummer: Cay10007712-1
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. L-902,688 is a highly potent agonist of the human PGE2 receptor, EP4. It...
| Schlagworte: | 5-[(1E,3R)-4,4-difluoro-3-hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone |
| Anwendung: | EP4 agonist |
| CAS | 634193-54-7 |
| MW: | 419.5 D |
ab 150,00 €
EP4 Antagonist 14
Artikelnummer: Cay38427-1
EP4 antagonist 14 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC50 value of 1.1 nM in a reporter assay using HEK293 cells expressing the human receptor. It inhibits PGE2-induced beta-arrestin recruitment in the same cells (IC50 = 0.9 nM). EP4 antagonist 14 (10 µM) decreases...
| Schlagworte: | PGE2 Receptor 4 Antagonist 14, Prostaglandin E2 Receptor 4 Antagonist 14,... |
| Anwendung: | EP4 receptor (prostaglandin E receptor 4) antagonist |
| MW: | 453.4 D |
ab 90,00 €
AMX12006
Artikelnummer: Cay39027-10
AMX12006 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 4.3 nM). It is selective for EP4 over EP1, EP2, and EP3 receptors (IC50s = >10 µM for all). AMX12006 is cytotoxic to MCF-7 and 4T1 breast and CT26 colon cancer cells (IC50s = 46.73, 79.47, and 41.39 µM, respectively). It reduces...
| Schlagworte: | 4-[(1S)-1-[[[1-methyl-3-[[3-(trifluoromethyl)phenyl]amino]-1H-indol-2-yl]carbonyl]amino]ethyl]-benzoic acid |
| Anwendung: | EP4 receptor (prostaglandin E receptor 4) antagonist |
| CAS | 2639775-01-0 |
| MW: | 481.5 D |
ab 77,00 €
L-161,982
Artikelnummer: Cay10011565-1
Prostaglandin E2 (PGE2) exerts its effects through four separate G coupled-protein receptors (EP1-4). L-161,982 is a potent and selective EP4 receptor antagonist. It demonstrates selective binding to human EP4 receptors with a Ki value of 0.024 µM compared to other receptors of the prostanoid family, EP1, EP2, EP3,...
| Schlagworte: | N-[[4'-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfony... |
| Anwendung: | EP4 receptor antagonist |
| CAS | 147776-06-5 |
| MW: | 654.7 D |
ab 50,00 €
CAY10598
Artikelnummer: Cay13281-500
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10598 is a very potent agonist of EP4, binding with a Ki value of 1.2...
| Schlagworte: | 5-[(3S)-3-hydroxy-4-phenyl-1-buten-1-yl]1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone |
| Anwendung: | EP4 agonist |
| CAS | 346673-06-1 |
| MW: | 383.5 D |
ab 129,00 €
ONO-AE3-208
Artikelnummer: Cay14522-5
ONO-AE3-208 is an antagonist of the EP4 receptor (Ki = 1.3 nM) which less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors. In wild type mice, it mimics deletion of EP4 by producing severe colitis, with epithelial loss, crypt...
| Schlagworte: | 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-benzenebutanoic acid |
| Anwendung: | EP4 receptor antagonist |
| CAS | 402473-54-5 |
| MW: | 404.4 D |
ab 60,00 €
CJ-42794
Artikelnummer: Cay10010428-10
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-42794 is a selective antagonist of EP4 (Ki = 3.16 nM) that less...
| Schlagworte: | RQ-00015986, 4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]-benzoic acid |
| Anwendung: | EP4 receptor agonist |
| CAS | 847728-01-2 |
| MW: | 413.8 D |
ab 72,00 €
CJ-023423
Artikelnummer: Cay10010355-1
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-023423 is a potent and selective antagonist of the EP4 receptor (Ki =...
| Schlagworte: | Grapiprant, RQ-00000007,... |
| Anwendung: | EP4R antagonist |
| CAS | 415903-37-6 |
| MW: | 491.6 D |
ab 43,00 €
CAY10684
Artikelnummer: Cay15966-1
Prostaglandin E2 (PGE2, Cay-14010) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a G protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10684 is a lactam that acts as a potent EP4 agonist,...
| Schlagworte: | (2R)-2-[(1E)-3-(4'-chloro-2'-methyl[1,1'-biphenyl]-3-yl)-3-hydroxy-1-propen-1-yl]-5-oxo-1-pyrrolidineheptanoic acid |
| Anwendung: | EP4 agonist |
| CAS | 493035-81-7 |
| MW: | 470 D |
ab 127,00 €
tetranor-Misoprostol
Artikelnummer: Cay22693-25
tetranor-Misoprostol is a metabolite of misoprostol (Cay-13820). It is formed when misoprostol undergoes rapid de-esterification to form misoprostol (free acid) (Cay-13821), which is further metabolized to form the more polar tetranor-misoprostol in rats, dogs, and monkeys.Formal Name:...
| Schlagworte: | 3-((1R,2R,3R)-3-hydroxy-2-((E)-4-hydroxy-4-methyloct-1-en-1-yl)-5-oxocyclopentyl)propanoic acid |
| Anwendung: | Misoprostol metabolite |
| MW: | 312.4 D |
ab 179,00 €
E7046
Artikelnummer: Cay19673-10
E7046 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (IC50 = 13.5 nM). It inhibits PGE2-induced activation of pro-tumor type 2 macrophages and prevents PGE2-induced suppression of T cell proliferation in isolated human peripheral blood monocytes (PBMCs) when used at concentrations ranging from...
| Schlagworte: | 4-[(1S)-1-[[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazol-4-yl]carbonyl]amino]ethyl]-benzoic acid |
| Anwendung: | EP4 antagonist |
| CAS | 1369489-71-3 |
| MW: | 483.4 D |
ab 60,00 €
EP4 Receptor Antagonist 1
Artikelnummer: Cay32722-5
EP4 receptor antagonist 1 is an antagonist of the prostaglandin E2 (PGE2) receptor EP4 that has an IC50 value of 6.1 nM in a calcium flux assay using CHO cells co-expressing the human receptor and Galpha16. It is selective for EP4 over EP1, EP2, and EP3 receptors (IC50s = >10,000 nM for all). EP4 receptor antagonist...
| Schlagworte: | 4-[(1S)-1-[[[4-(1E)-1-propen-1-yl-1-[[4-(trifluoromethyl)phenyl]methyl]-1H-1,2,3-triazol-5-yl]carbonyl]amino]ethyl]-benzoi... |
| Anwendung: | EP4 receptor antagonist |
| CAS | 2287259-07-6 |
| MW: | 458.4 D |
ab 92,00 €