C-DIM8

C-DIM8 is a para-phenyl-substituted diindolylmethane (C-DIM) and an antagonist of the orphan receptor nuclear receptor-related protein 77 (Nur77). It inhibits reporter gene expression induced by the Nur77 agonist C-DIM5 (Cay-27980) in PANC-28 cells when used at a concentration of 20 µM. C-DIM8 (10, 15, and 20 µM) reduces expression of BIRC5, the gene encoding survivin, in PANC-1 pancreatic cancer cells. In vivo, C-DIM8 (30 mg/kg) induces tumor cell apoptosis and reduces tumor volume in an L3.6pl pancreatic carcinoma mouse xenograft model.Formal Name: 4-(di-1H-indol-3-ylmethyl)-phenol. CAS Number: 151358-47-3. Synonyms: DIM-C-pPhOH, 1,1-bis-(3'-indolyl)-1-(p-hydroxyphenyl)methane. Molecular Formula: C23H18N2O. Formula Weight: 338.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. lambdamax: 212, 262 nm. SMILES: OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1. InChi Code: InChI=1S/C23H18N2O/c26-16-11-9-15(10-12-16)23(19-13-24-21-7-3-1-5-17(19)21)20-14-25-22-8-4-2-6-18(20)22/h1-14,23-26H. InChi Key: QCPDFNWJBQMXLI-UHFFFAOYSA-N.