BSP-16

BSP-16 is a stimulator of interferon genes (STING) agonist. It binds to STING (Kd = 23 µM) and induces the production of IFN-beta, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells when used at concentrations of 10, 25, and 50 µM. BSP-16 (50 µM) induces phosphorylation of IFN regulatory factor 3 (IRF3) and TANK-binding kinase 1 (TBK1) in THP-1 cells. In vivo, BSP-16 (15 and 30 mg/kg) reduces tumor volume in an MC-38 murine carcinoma model and induces tumor regression in a CT26 murine colorectal carcinoma model. It prevents tumor cell re-challenge-induced tumor formation in a CT26 murine carcinoma model. BSP-16 (20 mg/kg) also reduces tumor volume and increases the number of activated CD8+ T cells and natural killer (NK) cells in a 4T1 murine mammary carcinoma model.Formal Name: alphaR-ethyl-5,6-dimethoxy-gamma-oxo-benzo[b]selenophene-2-butanoic acid. CAS Number: 2727249-47-8. Synonyms: LF250. Molecular Formula: C16H18O5Se. Formula Weight: 369.3. Purity: >98%. Formulation: (Request formulation change), A solid. lambdamax: 218, 332 nm. SMILES: O=C(C[C@@H](CC)C(O)=O)C1=CC2=CC(OC)=C(OC)C=C2[Se]1. InChi Code: InChI=1S/C16H18O5Se/c1-4-9(16(18)19)5-11(17)15-7-10-6-12(20-2)13(21-3)8-14(10)22-15/h6-9H,4-5H2,1-3H3,(H,18,19)/t9-/m1/s1. InChi Key: BWQHPFYQJHFPHN-SECBINFHSA-N.