Zu "K12654" wurden 200 Artikel gefunden!
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Anti-Recombinant STING, clone A369
Artikelnummer: E-AN301666L.100
STING has several transmembrane domains, and is expressed in a variety of endothelial cells, epithelial cells and hematopoietic liver cells. STING participates in the DNA-mediated innate immune response. Non-CpG double-stranded DNA from viruses or bacteria binds to cGAS protein and is catalyzed to the second...
| Schlagworte: | Anti-STING1, Anti-Transmembrane protein 173, Anti-Mediator of IRF3 activation, Anti-Stimulator of interferon genes... |
| Anwendung: | WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 304,00 €
Anti-Recombinant TMEM173, clone 6G8
Artikelnummer: E-AN301084L.100
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded...
| Schlagworte: | Anti-STING1, Anti-Transmembrane protein 173, Anti-Mediator of IRF3 activation, Anti-Stimulator of interferon genes... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-STING1 / Stimulator of interferon genes / TMEM173
Artikelnummer: NSJ-FY13022
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. STING1 antibody detects Stimulator of interferon genes (TMEM173), a central adaptor protein in the cytosolic DNA-sensing pathway that activates type I interferon responses. The UniProt recommended name is Stimulator of interferon genes...
| Schlagworte: | Anti-STING1, Anti-Transmembrane protein 173, Anti-Mediator of IRF3 activation, Anti-Stimulator of interferon genes... |
| Anwendung: | WB, IHC, ICC/IF, FC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
SNX-281
Artikelnummer: Cay44273-1
SNX-281 is an agonist of stimulator of interferon genes (STING). InChI: InChI=1S/C20H20ClNO3S/c1-20(2,3)11-5-6-12-15(9-11)22(10-16(23)24)17-13(18(12)25)7-8-14(21)19(17)26-4/h5-9H,10H2,1-4H3,(H,23,24) InChIKey: CLGJCTXUWJLYHO-UHFFFAOYSA-N SMILES: O=C(O)CN1C2=C(C(Cl)=CC=C2C(C3=CC=C(C=C31)C(C)(C)C)=O)SC
| Schlagworte: | 3-chloro-6-(1,1-dimethylethyl)-4-(methylthio)-9-oxo-10(9H)-acridineacetic acid |
| Anwendung: | STING agonist |
| CAS | 2332803-84-4 |
| MW: | 389.89 D |
ab 147,00 €
MK-2118
Artikelnummer: Cay44275-1
MK-2118 is an agonist of stimulator of interferon genes (STING). It induces STING signaling in a reporter assay using membranes expressing human STING (EC50 = 2. µM). MK-2118 (30 µM) induces IFN-beta secretion in THP-1 monocytes. InChI:...
| Schlagworte: | (alphaS)-5,6-dimethoxy-alpha-methyl-gamma-oxo-benzo[b]thiophene-2-butanoic acid |
| Anwendung: | STING agonist |
| CAS | 2218504-06-2 |
| MW: | 308.35 D |
ab 141,00 €
-20 %
Rabattaktion
Anti-STING/TMEM173 Recombinant Monoclonal
Artikelnummer: A700-373
Protein function: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953, PubMed:23910378, PubMed:23747010,...
| Schlagworte: | Anti-ERIS, Anti-hMITA, Anti-hSTING, Anti-Transmembrane protein 173, Anti-Mediator of IRF3 activation, Anti-Stimulator of... |
| Anwendung: | WB, IP, IHC, ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
172,00 €
ab 137,60 €
-20 %
Rabattaktion
Anti-STING/TMEM173 Recombinant Monoclonal
Artikelnummer: A700-373CF
Protein function: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953, PubMed:23910378, PubMed:23747010,...
| Schlagworte: | Anti-ERIS, Anti-hMITA, Anti-hSTING, Anti-Transmembrane protein 173, Anti-Mediator of IRF3 activation, Anti-Stimulator of... |
| Anwendung: | WB, IP, IHC, ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
1.075,00 €
860,00 €
STING R232 variant (human, recombinant)
Artikelnummer: Cay22816-100
Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-kappaB and transcription of immunomodulatory genes, including type I interferon (IFN). The R232 variant is the most common variant...
| Schlagworte: | ERIS, ERIS, hMITA, hMITA, hSTING, hSTING, Transmembrane protein 173, Transmembrane protein 173, Mediator of IRF3... |
| Anwendung: | ELISA, FC, WB |
875,00 €
STING H232 variant, SUMO-tagged (human, recombinant)
Artikelnummer: Cay15139-50
STING H232 variant, SUMO-tagged contains amino acids 155-341 of the H232 variant and a removable N-terminal SUMOpro tag. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-kappaB...
| Schlagworte: | ERIS, MITA, MPYS, Stimulator of Interferon Genes, TMEM173 |
| Anwendung: | Binding assays |
| Exprimiert in: | E.coli |
| MW: | 34,5 kD |
712,00 €
H-151
Artikelnummer: Cay25857-5
H-151 is an inhibitor of stimulator of interferon genes (STING). It forms an adduct with mouse STING in serum and acts in an irreversible manner. It inhibits the type I interferon (IFN) response and reduces the phosphorylation of TBK1 and palmitoylation of human STING (hsSTING) in vitro. It also reduces increases in...
| Schlagworte: | N-(4-ethylphenyl)-N'-1H-indol-3-yl-urea |
| Anwendung: | STING inhibitor |
| CAS | 941987-60-6 |
| MW: | 279.3 D |
ab 93,00 €
diABZI STING Agonist-1 (hydrochloride)
Artikelnummer: Cay28054-500
diABZI STING agonist-1 is an agonist of the stimulator of interferon genes (STING) pathway. It induces secretion of IFN-beta in human peripheral blood mononuclear cells (PBMCs, EC50 = 130 nM). diABZI STING agonist-1 (2.5 mg/kg) increases serum levels of IFN-beta, IL-6, TNF, and KC/GROalpha in wild-type, but not...
| Schlagworte: | 1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten... |
| Anwendung: | Stimulator of interferon genes pathway agonist |
| CAS | 2138299-34-8 |
| MW: | 959.3 D |
ab 235,00 €
diABZI STING Agonist 2
Artikelnummer: Cay34088-1
diABZI STING agonist 2 is an agonist of stimulator of interferon genes (STING). It binds to STING with an apparent Kd value of 1.6 nM. It is selective for STING over the acute phase reactant orosomucoid 1 (ORM1, apparent Kd = 79 nM). diABZI STING agonist 2 increases phosphorylation of interferon regulatory factor 3...
| Schlagworte: | CS-0087594, diABZI-4, Diamidobenzimidazole STING Agonist-2, HY-123943, STING Agonist diABZI Compound 2, STING Agonist-4,... |
| Anwendung: | STING agonist |
| CAS | 2138300-40-8 |
| MW: | 678.7 D |
ab 93,00 €