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Zu "K12654" wurden 104 Artikel gefunden!
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NEU
Artikelnummer: Cay40481-1
PDIC-NS is an activator of stimulator of interferon genes (STING). It increases the levels of reactive oxygen species (ROS) and induces apoptosis in LL/2 lung carcinoma cells when used at a concentration of 2.5 µM. PDIC-NS (2.5 µM) induces cell cycle arrest at the S phase, increases cytosolic levels of mitochondrial...
Anwendung: | STING activator |
MW: | 862.6 D |
ab 34,00 €
Artikelnummer: Cay39274-1
STING PROTAC SP23 is a proteolysis-targeting chimera (PROTAC) containing the stimulator of interferon genes (STING) inhibitor C-170 (Cay-30157) conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877) via an alpha,beta-unsaturated carbonyl linker. It degrades STING in THP-1 cells with a half-maximal...
Schlagworte: | PROTAC Stimulator of Interferon Genes Degrader-1, PROTAC STING Degrader-1, Proteolysis-targeting Chimera Stimulator of... |
Anwendung: | STING degradation driving PROTAC |
CAS | 2762552-74-7 |
MW: | 699.7 D |
181,00 €
Artikelnummer: Cay39708-1
BDW568 is an agonist of stimulator of interferon genes (STING) and a prodrug form of BDW-OH. It induces STING transcriptional activity in a reporter assay using THP-1 cells (EC50 = 7.6 µM). BDW568 (50 µM) induces phosphorylation of TANK-binding kinase 1 (TBK1) and IFN regulatory factor 3 (IRF3) in THP-1 cells.Formal...
Schlagworte: | 2-[(8,9-dimethylthieno[3,2-e]-1,2,4-triazolo[4,3-c]pyrimidin-3-yl)thio]-acetic acid, methyl ester |
Anwendung: | STING agonist, BDW-OH prodrug |
CAS | 335401-44-0 |
MW: | 308.4 D |
ab 80,00 €
Artikelnummer: Cay39832-1
LB244 is an irreversible STING antagonist. It binds to STING in a cell-free assay and inhibits STING activation induced by the STING agonist diABZI in cells (EC50 = 0.8 nM). LB244 (1 µM) inhibits diABZI-induced STING oligomerization and phosphorylation of IFN regulatory factor 3 (IRF3) and TANK-binding kinase 1...
Schlagworte: | (R)-N-(4-([1,1'-biphenyl]-4-carboxamido)-4-(1H-benzo[d]imidazol-2-yl)butyl)-5-nitrofuran-2-carboxamide |
Anwendung: | Irreversible STING antagonist |
MW: | 523.5 D |
ab 106,00 €
Artikelnummer: ELK-ELK7591.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TMEM173. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TMEM173....
Schlagworte: | ERIS, hMITA, hSTING, Transmembrane protein 173, Mediator of IRF3 activation, Stimulator of interferon genes protein,... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: Cay38706-1
STING agonist D61 (D61) is an agonist of stimulator of interferon genes (STING). It induces expression of an IFN3-inducible secreted alkaline phosphatase (SEAP) reporter gene and an IFN-beta-inducible reporter gene in cell-based assays (EC50s = 52.9 and 116 nM, respectively). D61 (4, 6, and 8 µM) increases the...
Schlagworte: | D61, Stimulator of Interferon Genes Agonist D61,... |
Anwendung: | STING agonist |
CAS | 2850251-27-1 |
MW: | 610.6 D |
ab 90,00 €
Artikelnummer: Cay38344-1
STING agonist 12L is an agonist of stimulator of interferon genes (STING). It binds to wild-type STING (IC50 = 1.15 µM), as well as the STING R232, AQ, and Q variants (IC50s = 1.06, 0.61, and 1.12 µM, respectively) and induces reporter gene expression in THP-1 and RAW 264.7 cells (EC50s = 0.38 and 12.94 µM,...
Schlagworte: | Stimulator of Interferon Genes Agonist 12L, 2-([3,4'-bipyridazine]-6-carboxamido)-4-ethynyl-5-fluorobenzoic acid |
Anwendung: | STING agonist |
CAS | 2913152-30-2 |
MW: | 363.3 D |
ab 117,00 €
Artikelnummer: Cay38899-10
SN-001 is an inhibitor of stimulator of interferon genes (STING). It inhibits herring testis DNA-induced Ifnb mRNA expression in L-929 cells (IC50 = 3.82 µM).Formal Name: N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-methoxyphenyl]-[1,1'-biphenyl]-4-carboxamide. CAS Number: 727699-84-5. Synonyms: DUN99845, Stimulator of...
Schlagworte: | DUN99845, Stimulator of Interferon Genes Inhibitor 1, STING Inhibitor 1,... |
Anwendung: | STING inhibitor |
CAS | 727699-84-5 |
MW: | 476.5 D |
ab 68,00 €
Artikelnummer: Cay37992-1
BSP-16 is a stimulator of interferon genes (STING) agonist. It binds to STING (Kd = 23 µM) and induces the production of IFN-beta, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells when used at concentrations of 10, 25, and 50 µM. BSP-16 (50 µM) induces phosphorylation of IFN regulatory factor 3...
Schlagworte: | LF250, alphaR-ethyl-5,6-dimethoxy-gamma-oxo-benzo[b]selenophene-2-butanoic acid |
Anwendung: | STING agonist |
CAS | 2727249-47-8 |
MW: | 369.3 D |
ab 204,00 €
Artikelnummer: Cay15139-50
STING H232 variant, SUMO-tagged contains amino acids 155-341 of the H232 variant and a removable N-terminal SUMOpro tag. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-kappaB...
Schlagworte: | ERIS, MITA, MPYS, Stimulator of Interferon Genes, TMEM173 |
Anwendung: | Binding assays |
Exprimiert in: | E.coli |
MW: | 34,5 kD |
642,00 €
Artikelnummer: Cay38345-10
STING agonist 23 is an agonist of stimulator of interferon genes (STING). It increases the phosphorylation of TANK-binding kinase 1 (TBK1) in wild-type, but not STING-deficient, HT-1080 cells when used at a concentration of 20 µM. STING agonist 23 induces dimerization of STING in THP-1 cells and mouse bone...
Schlagworte: | Stimulator of Interferon Genes Agonist 23, N,N'-(pentane-1,5-diyl)bis(5-nitrofuran-2-carboxamide) |
Anwendung: | STING agonist |
MW: | 380.3 D |
ab 54,00 €
Artikelnummer: Cay25857-10
H-151 is an inhibitor of stimulator of interferon genes (STING). It forms an adduct with mouse STING in serum and acts in an irreversible manner. It inhibits the type I interferon (IFN) response and reduces the phosphorylation of TBK1 and palmitoylation of human STING (hsSTING) in vitro. It also reduces increases in...
Schlagworte: | N-(4-ethylphenyl)-N'-1H-indol-3-yl-urea |
Anwendung: | STING inhibitor |
CAS | 941987-60-6 |
MW: | 279.3 D |
ab 84,00 €