BIBF 0775

BIBF 0775 is an inhibitor of TGF-beta receptor type 1 (ALK5, IC50 = 34 nM). It is selective for ALK5 over VEGFR2 and PDGFRalpha (IC50s = 1,447 and 890 nM, respectively), as well as a panel of 30 other kinases at 1 µM. BIBF 0775 inhibits the phosphorylation of SMAD2 and SMAD3 in HaCaT cells (EC50 = 105 nM) and is not cytotoxic to HaCaT cells (IC50 = >1,000 nM).Formal Name: (3Z)-N-ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indole-6-carboxamide. CAS Number: 334951-90-5. Molecular Formula: C31H34N4O2. Formula Weight: 494.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 5 mg/ml, Ethanol: 2 mg/ml. lambdamax: 283, 387 nm. SMILES: O=C1NC2=CC(C(N(C)CC)=O)=CC=C2/C1=C(C3=CC=CC=C3)/NC4=CC=C(C=C4)CN5CCCCC5. InChi Code: InChI=1S/C31H34N4O2/c1-3-34(2)31(37)24-14-17-26-27(20-24)33-30(36)28(26)29(23-10-6-4-7-11-23)32-25-15-12-22(13-16-25)21-35-18-8-5-9-19-35/h4,6-7,10-17,20,32H,3,5,8-9,18-19,21H2,1-2H3,(H,33,36)/b29-28-. InChi Key: MUSRTIADFPCYTQ-ZIADKAODSA-N.