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Zu "K04674" wurden 98 Artikel gefunden!
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Artikelnummer: Cay13031-25
SB-431542 is a potent and selective inhibitor of the TGF-beta1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene...
Schlagworte: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide, hydrate |
Anwendung: | ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor |
MW: | 384.4 D |
ab 43,00 €
Artikelnummer: CSB-EP023451HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 34-126aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: LQCFCHLCTK DNFTCVTDGL CFVSVTETTD KVIHNSMCIA EIDLIPRDRP FVCAPSSKTG SVTTTYCCNQ DHCNKIELPT TVKSSPGLGP VEL. Purity: Greater than 90%...
Schlagworte: | ALK5, SKR4, ALK-5, TGFBR1, TGFR-1, TbetaR-I, EC=2.7.11.30, TGF-beta receptor type-1, TGF-beta receptor type I, TGF-beta... |
Anwendung: | Activity not tested |
Exprimiert in: | E.coli |
Ursprungsart: | human |
MW: | 17.6 kD |
ab 283,00 €
Artikelnummer: CSB-MP023451HU2.1
Organism: Homo sapiens (Human). Source: Mammalian cell. Expression Region: 34-125aa. Protein Length: Partial. Tag Info: C-terminal hFC-tagged. Target Protein Sequence: LQCFCHLCTK DNFTCVTDGL CFVSVTETTD KVIHNSMCIA EIDLIPRDRP FVCAPSSKTG SVTTTYCCNQ DHCNKIELPT TVKSSPGLGP VE. Purity: Greater than 90% as determined by...
Schlagworte: | ALK5, SKR4, ALK-5, TGFBR1, TGFR-1, TbetaR-I, EC=2.7.11.30, TGF-beta receptor type-1, TGF-beta receptor type I, TGF-beta... |
Anwendung: | Activity not tested |
Exprimiert in: | Mammalian cells |
Ursprungsart: | human |
MW: | 39.0 kD |
ab 216,00 €
Artikelnummer: DIM-PME100103.10
Recombinant human TGFBR1 Protein with N-terminal Human Fc tag. hFc(Glu99-Ala330) TGFBR1(Leu34-Leu126), Protein function: Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3....
Schlagworte: | AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, tbetaR-I, TBR-i, TBRI, TGFR-1 |
Exprimiert in: | Human cells |
Ursprungsart: | human |
MW: | 36.3 kD |
ab 95,00 €
Artikelnummer: DIM-PME100777.10
Recombinant human TGFBR1 protein with C-terminal Human Fc tag. TGFBR1(Leu34-Leu126) hFc(Glu99-Ala330), Protein function: Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3....
Schlagworte: | AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, tbetaR-I, TBR-i, TBRI, TGFR-1 |
Exprimiert in: | Human cells |
Ursprungsart: | human |
CAS | 12 |
MW: | 36.3 kD |
ab 168,00 €
Artikelnummer: CSB-PA004276.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
Schlagworte: | Anti-ALK5, Anti-SKR4, Anti-ALK-5, Anti-TGFR-1, Anti-TGFBR1, Anti-TbetaR-I, EC=2.7.11.30, Anti-TGF-beta receptor type I,... |
Anwendung: | ELISA, WB, IF |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 106,00 €
Artikelnummer: CSB-PA050248.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
Schlagworte: | Anti-phospho-ALK5, Anti-phospho-SKR4, Anti-phospho-ALK-5, Anti-phospho-TGFR-1, Anti-phospho-TGFBR1, Anti-phospho-TbetaR-I,... |
Anwendung: | ELISA, WB, IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 106,00 €
Artikelnummer: CSB-PA061850.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
Schlagworte: | Anti-ALK5, Anti-SKR4, Anti-ALK-5, Anti-TGFR-1, Anti-TGFBR1, Anti-TbetaR-I, EC=2.7.11.30, Anti-TGF-beta receptor type I,... |
Anwendung: | ELISA, WB, IF |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse |
275,00 €
Artikelnummer: CSB-PA206147.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: TGFBR1. Antigen Species: Human
Schlagworte: | Anti-ALK5, Anti-SKR4, Anti-ALK-5, Anti-TGFR-1, Anti-TGFBR1, Anti-TbetaR-I, EC=2.7.11.30, Anti-TGF-beta receptor type I,... |
Anwendung: | ELISA, IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 163,00 €
Artikelnummer: CSB-PA699479.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: TGFBR1. Antigen Species: Human
Schlagworte: | Anti-ALK5, Anti-SKR4, Anti-ALK-5, Anti-TGFR-1, Anti-TGFBR1, Anti-TbetaR-I, EC=2.7.11.30, Anti-TGF-beta receptor type I,... |
Anwendung: | ELISA, IHC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 163,00 €
Artikelnummer: Cay14794-25
ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-beta type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-beta cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 µM) when...
Schlagworte: | E 616452, RepSox, SJN 2511, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine |
Anwendung: | ALK5 inhibitor |
CAS | 446859-33-2 |
MW: | 287.3 D |
ab 35,00 €
Artikelnummer: Cay9001799-10
A 83-01 is an inhibitor of TGF-beta type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively). It blocks the phosphorylation of SMAD2/3 and inhibits TGF-beta-induced epithelial-to-mesenchymal transition. It has little effect on bone...
Schlagworte: | 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
Anwendung: | TGFBR1 inhibitor |
CAS | 909910-43-6 |
MW: | 421.5 D |
ab 39,00 €