Zu "K04674" wurden 123 Artikel gefunden!
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SB-431542 (hydrate)
Artikelnummer: Cay13031-10
SB-431542 is a potent and selective inhibitor of the TGF-beta1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene...
| Schlagworte: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide, hydrate |
| Anwendung: | ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor |
| MW: | 384.4 D |
ab 53,00 €
ALK5 Inhibitor II
Artikelnummer: Cay14794-25
ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-beta type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-beta cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 µM) when...
| Schlagworte: | E 616452, RepSox, SJN 2511, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine |
| Anwendung: | ALK5 inhibitor |
| CAS | 446859-33-2 |
| MW: | 287.3 D |
ab 44,00 €
TGFBR1, mFc Chimera, Avi, Human
Artikelnummer: GSC-Z05874-100
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR-98-5p. miR-98-5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells.
| Schlagworte: | TGFBR1, TGF-beta type I receptor, TGF-beta receptor type-1, Activin receptor-like kinase 5, Serine/threonine-protein... |
| Ursprungsart: | human |
| MW: | 38.2 kD |
ab 497,00 €
A 83-01
Artikelnummer: Cay9001799-10
A 83-01 is an inhibitor of TGF-beta type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively). It blocks the phosphorylation of SMAD2/3 and inhibits TGF-beta-induced epithelial-to-mesenchymal transition. It has little effect on bone...
| Schlagworte: | 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
| Anwendung: | TGFBR1 inhibitor |
| CAS | 909910-43-6 |
| MW: | 421.5 D |
ab 49,00 €
LY2157299
Artikelnummer: Cay15312-1
LY2157299 is a small molecule inhibitor of the TGF-beta receptor type 1 kinase (IC50 = 56 nM). It has been used to study the role of TGF-beta signaling in chemotherapy-induced expansion of cancer stem-like cells in triple negative breast cancer cell lines and xenografts. LY2157299 has also been shown to inhibit the...
| Schlagworte: | Galunisertib, 4-[5,6-dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide |
| Anwendung: | TGFBR1 inhibitor |
| CAS | 700874-72-2 |
| MW: | 369.4 D |
ab 73,00 €
IN 1130
Artikelnummer: Cay43285-10
IN 1130 is an inhibitor of activin receptor-like kinase 5 (ALK5), also known as TGF-beta receptor type 1 (TGF-betaRI, IC50 = 5. nM). It is selective for ALK5 over a panel of 27 other kinases at 5 µM. IN 1130 (10 mg/kg per day) decreases renal fibrogenesis, inflammatory cell infiltration, and tubular atrophy in a...
| Schlagworte: | 3-[[5-(6-methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]-benzamide |
| Anwendung: | ALK5 inhibitor |
| CAS | 868612-83-3 |
| MW: | 420.48 D |
ab 147,00 €
SB-431542
Artikelnummer: LKT-S0400.1
SB-431542 inhibits activin receptor-like kinases ALK4, ALK5, and ALK7, this inhibition leads to inhibition of activin and TGF- signaling with no downstream effects on ERK, JNK, or MAPK. SB-431542 exhibits anti-angiogenic and anticancer activity. In vitro, SB-431542 inhibits proliferation and motility of glioma...
| Anwendung: | ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor |
| CAS | 301836-41-9 |
| MW: | 384.39 D |
ab 100,00 €
LY2109761
Artikelnummer: Cay15409-5
LY2157299 is a small molecule inhibitor of the TGF-beta receptor type 1/type II kinases (IC50 = 69 nM). It has been used to study the role of TGF-beta signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where 5 µM of the compound completely disrupts Smad-2 phosphorylation, an immediate...
| Schlagworte: | 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]-quinoline |
| Anwendung: | TGFBR1/2 inhibitor |
| CAS | 700874-71-1 |
| MW: | 441.5 D |
ab 67,00 €
LY364947
Artikelnummer: Cay13341-5
Transforming growth factor-beta (TGF-beta) signals through a cell surface heteromeric complex involving type I (TGF-beta RI) and type II (TGF-beta RII) receptors. Downstream signal transduction is mediated by the TGF-beta RI kinase domain through the phosphorylation of Smad proteins. LY364947 is a selective...
| Schlagworte: | HTS 466284, TGF-beta RI Kinase Inhibitor, 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline |
| Anwendung: | TGFbetaRI inhibitor |
| CAS | 396129-53-6 |
| MW: | 272.3 D |
ab 100,00 €
ALK5 Inhibitor II (hydrochloride)
Artikelnummer: Cay15526-1
ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-beta type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-beta cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 µM) when...
| Schlagworte: | E 616452, RepSox, SJN 2511, 2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, monohydrochloride |
| Anwendung: | TGFBR1 inhibitor |
| CAS | 2319939-07-4 |
| MW: | 323.8 D |
ab 50,00 €
SB-505124
Artikelnummer: Cay11793-1
SB-505124 inhibits the TGF-beta1 receptor serine/threonine kinase ALK5 with an IC50 value of 47 nM. Though it is a less potent antagonist of ALK4 (IC50 = 129 nM) and ALK7, SB-505124 selectively and concentration-dependently inhibits ALK4-, ALK5-, and ALK7-dependent activation of downstream SMAD2 and SMAD3 and...
| Schlagworte: | 2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine |
| Anwendung: | ALK5 inhibitor |
| CAS | 694433-59-5 |
| MW: | 335.4 D |
ab 56,00 €
GW-788388
Artikelnummer: LKT-G8800.1
ALK5 (activin-like) antagonist.
| Anwendung: | ALK5 (activin-like) antagonist |
| CAS | 452342-67-5 |
| MW: | 425.49 D |
ab 104,00 €