Zu "K04674" wurden 131 Artikel gefunden!
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SB-431542 (hydrate)
Artikelnummer: Cay13031-10
SB-431542 is a potent and selective inhibitor of the TGF-beta1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene...
| Schlagworte: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide, hydrate |
| Anwendung: | ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor |
| MW: | 384.4 D |
ab 55,00 €
ALK5 Inhibitor II
Artikelnummer: Cay14794-25
ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-beta type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-beta cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 µM) when...
| Schlagworte: | E 616452, RepSox, SJN 2511, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine |
| Anwendung: | ALK5 inhibitor |
| CAS | 446859-33-2 |
| MW: | 287.3 D |
ab 45,00 €
NEU
TGF-beta RI Kinase Inhibitor VII
Artikelnummer: Cay45225-10
An ALK5 inhibitor (IC50 = 0.63 µM), selective for ALK5 over c-Src (IC50 = 13 µM), inhibits SMAD2 phosphorylation in A549 cell lysates from 0.15-5 µM. SMILES: O=C(C)C1=C(OC2=C(C=C(C(OC)=C3)OC)C3=NC=C2)C=C(C)C(C)=C1. InChi Code:...
| Schlagworte: | 1-[2-[(6,7-dimethoxy-4-quinolinyl)oxy]-4,5-dimethylphenyl]-ethanone |
| Anwendung: | TGF-beta receptor type-1 (ALK5) inhibitor |
| CAS | 666729-57-3 |
| MW: | 351.4 D |
ab 203,00 €
A 83-01
Artikelnummer: Cay9001799-10
A 83-01 is an inhibitor of TGF-beta type I receptor kinase (ALK5), activin type IB receptor (ALK4), and nodal type I receptor (ALK7) (IC50s = 12, 45, and 7.5 nM, respectively). It blocks the phosphorylation of SMAD2/3 and inhibits TGF-beta-induced epithelial-to-mesenchymal transition. It has little effect on bone...
| Schlagworte: | 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
| Anwendung: | TGFBR1 inhibitor |
| CAS | 909910-43-6 |
| MW: | 421.5 D |
ab 51,00 €
LY2157299
Artikelnummer: Cay15312-1
LY2157299 is a small molecule inhibitor of the TGF-beta receptor type 1 kinase (IC50 = 56 nM). It has been used to study the role of TGF-beta signaling in chemotherapy-induced expansion of cancer stem-like cells in triple negative breast cancer cell lines and xenografts. LY2157299 has also been shown to inhibit the...
| Schlagworte: | Galunisertib, 4-[5,6-dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide |
| Anwendung: | TGFBR1 inhibitor |
| CAS | 700874-72-2 |
| MW: | 369.4 D |
ab 76,00 €
SB-431542
Artikelnummer: LKT-S0400.1
SB-431542 inhibits activin receptor-like kinases ALK4, ALK5, and ALK7, this inhibition leads to inhibition of activin and TGF- signaling with no downstream effects on ERK, JNK, or MAPK. SB-431542 exhibits anti-angiogenic and anticancer activity. In vitro, SB-431542 inhibits proliferation and motility of glioma...
| Anwendung: | ALK4 inhibitor, ALK5 inhibitor, ALK7 inhibitor |
| CAS | 301836-41-9 |
| MW: | 384.39 D |
ab 100,00 €
LY2109761
Artikelnummer: Cay15409-5
LY2157299 is a small molecule inhibitor of the TGF-beta receptor type 1/type II kinases (IC50 = 69 nM). It has been used to study the role of TGF-beta signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where 5 µM of the compound completely disrupts Smad-2 phosphorylation, an immediate...
| Schlagworte: | 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]-quinoline |
| Anwendung: | TGFBR1/2 inhibitor |
| CAS | 700874-71-1 |
| MW: | 441.5 D |
ab 69,00 €
LY364947
Artikelnummer: Cay13341-5
Transforming growth factor-beta (TGF-beta) signals through a cell surface heteromeric complex involving type I (TGF-beta RI) and type II (TGF-beta RII) receptors. Downstream signal transduction is mediated by the TGF-beta RI kinase domain through the phosphorylation of Smad proteins. LY364947 is a selective...
| Schlagworte: | HTS 466284, TGF-beta RI Kinase Inhibitor, 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline |
| Anwendung: | TGFbetaRI inhibitor |
| CAS | 396129-53-6 |
| MW: | 272.3 D |
ab 104,00 €
ALK5 Inhibitor II (hydrochloride)
Artikelnummer: Cay15526-1
ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-beta type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-beta cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 µM) when...
| Schlagworte: | E 616452, RepSox, SJN 2511, 2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, monohydrochloride |
| Anwendung: | TGFBR1 inhibitor |
| CAS | 2319939-07-4 |
| MW: | 323.8 D |
ab 53,00 €
SB-505124
Artikelnummer: Cay11793-1
SB-505124 inhibits the TGF-beta1 receptor serine/threonine kinase ALK5 with an IC50 value of 47 nM. Though it is a less potent antagonist of ALK4 (IC50 = 129 nM) and ALK7, SB-505124 selectively and concentration-dependently inhibits ALK4-, ALK5-, and ALK7-dependent activation of downstream SMAD2 and SMAD3 and...
| Schlagworte: | 2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine |
| Anwendung: | ALK5 inhibitor |
| CAS | 694433-59-5 |
| MW: | 335.4 D |
ab 58,00 €
GW-788388
Artikelnummer: LKT-G8800.1
ALK5 (activin-like) antagonist.
| Anwendung: | ALK5 (activin-like) antagonist |
| CAS | 452342-67-5 |
| MW: | 425.49 D |
ab 104,00 €
SB-431542
Artikelnummer: TGM-T1726-5mg
Description: SB-431542 is an inhibitor of ALK5/TGF-beta type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other proteins. SB 431542 can be used for induced differentiation of stem cells. Target: TGF-beta/Smad, ALK. Smiles:...
| Schlagworte: | SB 431542 |
| Anwendung: | Smad3 phosphorylation inhibitor, TGFBR1/ALK4/ALK7 kinase inhibitor |
| CAS | 301836-41-9 |
| MW: | 384.39 D |
ab 48,00 €