Bethanechol (chloride)

Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Cay-15592) in isolated guinea pig small intestine (IC50 = 127 µM). Bethanechol increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 µM). It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 µg/kg. Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.Formal Name: 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium, monochloride. CAS Number: 590-63-6. Synonyms: (±)-Bethanechol, Carbamyl-beta-methylcholine chloride, NSC 30783. Molecular Formula: C7H17N2O2 . Cl. Formula Weight: 196.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.1 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: CC(OC(N)=O)C[N+](C)(C)C.[Cl-]. InChi Code: InChI=1S/C7H16N2O2.ClH/c1-6(11-7(8)10)5-9(2,3)4,/h6H,5H2,1-4H3,(H-,8,10),1H. InChi Key: XXRMYXBSBOVVBH-UHFFFAOYSA-N.