BAY 85-3934

BAY 85-3934 is a pan-inhibitor of hypoxia-inducible factor prolyl hydroxylases (HIF-PH, IC50s = 0.48, 0.28, and 0.45 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It stabilizes HIF-1alpha and HIF-2alpha levels in HeLa cells in a concentration- and time-dependent manner. BAY 85-3934 (50 µM) induces cell-cycle arrest at the G2/S phase in MDA-MB-231 breast cancer cells. It decreases lactate dehydrogenase (LDH) release from PC12 cells in an in vitro model of ischemia induced by oxygen-glucose deprivation when used at a concentration of 100 µM. BAY 85-3934 (5 mg/kg) increases plasma erythropoietin and hemoglobin levels, as well as packed cell volume, in a rat model of gentamicin-induced kidney failure.Formal Name: 1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-3H-pyrazol-3-one. CAS Number: 1154028-82-6. Synonyms: Molidustat. Molecular Formula: C13H14N8O2. Formula Weight: 314.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: slightly soluble, Methanol: slightly soluble. lambdamax: 251, 286 nm. SMILES: O=C1C(N2C=CN=N2)=CNN1C3=NC=NC(N4CCOCC4)=C3. InChi Code: InChI=1S/C13H14N8O2/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2. InChi Key: IJMBOKOTALXLKS-UHFFFAOYSA-N.