Zu "K09592" wurden 126 Artikel gefunden!
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NEU
Recombinant Human EGLN3 Protein
Artikelnummer: ABS-PQ-3979.100
Tag: N-MBP & C-His. Modification: unmodified. Start Site: Leu11. End Site: Val210. Coverage: 0.85. Isoelectric Point: 6. Core Sequence: LEKIALEYIV PCLHEVGFCY LDNFLGEVVG DCVLERVKQL HCTGALRDGQ LAGPRAGVSK RHLRGDQITW IGGNEEGCEA ISFLLSLIDR LVLYCGSRLG KYYVKERSKA MVACYPGNGT GYVRHVDNPN GDGRCITCIY YLNKNWDAKL HGGILRIFPE...
| Schlagworte: | HPH-1, EGLN3, Egl nine homolog 3, Prolyl hydroxylase EGLN3, Hypoxia-inducible factor prolyl hydroxylase 3, Prolyl... |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 65.5 kD |
ab 270,00 €
NEU
Recombinant Human EGLN3 Protein
Artikelnummer: ABS-PQ-3979-L.100
Tag: N-MBP & C-His. Modification: unmodified. Start Site: Leu11. End Site: Val210. Coverage: 0.85. Isoelectric Point: 6. Core Sequence: LEKIALEYIV PCLHEVGFCY LDNFLGEVVG DCVLERVKQL HCTGALRDGQ LAGPRAGVSK RHLRGDQITW IGGNEEGCEA ISFLLSLIDR LVLYCGSRLG KYYVKERSKA MVACYPGNGT GYVRHVDNPN GDGRCITCIY YLNKNWDAKL HGGILRIFPE...
| Schlagworte: | HPH-1, EGLN3, Egl nine homolog 3, Prolyl hydroxylase EGLN3, Hypoxia-inducible factor prolyl hydroxylase 3, Prolyl... |
| Exprimiert in: | Human cells |
| Ursprungsart: | human |
| MW: | 65.5 kD |
ab 295,00 €
NEU
Vadadustat-d5
Artikelnummer: Cay45871-100
Vadadustat-d5 is intended for use as an internal standard for the quantification of vadadustat (Cay-15295) by GC- or LC-MS. Vadadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 1 (HIF-PH1), HIF-PH2, and HIF-PH3 (Kis = 0.19, 0.26, and 0.56 nM, respectively). It stabilizes HIF-1alpha and...
| Schlagworte: | N-[[5-(3-chlorophenyl-2,4,6-d3)-3-hydroxy-2-pyridinyl]carbonyl]-glycine-2,2-d2 |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification, HIF-PH1/2/3 inhibitor |
| CAS | 2229917-78-4 |
| MW: | 311.73 D |
230,00 €
Anti-EGLN1 / Egl nine homolog 1 / PHD2
Artikelnummer: NSJ-FY13439
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. EGLN1 antibody targets Egl nine homolog 1, encoded by the EGLN1 gene. Egl nine homolog 1, also known as prolyl hydroxylase domain protein 2, is a cytoplasmic and nuclear enzyme that functions as a central oxygen sensor in mammalian cells....
| Schlagworte: | Anti-SM-20, Anti-EGLN1, Anti-Egl nine homolog 1, Anti-Hypoxia-inducible factor prolyl hydroxylase 2, Anti-Prolyl... |
| Anwendung: | WB, FC, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Daprodustat
Artikelnummer: TGM-T3197-5mg
Description: Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor. Target: HIF/HIF Prolyl-Hydroxylase, HIF. Smiles: OC(=O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C2CCCCC2)C1=O. References: Brigandi RA, et al. Am J Kidney Dis. 2016. doi: 10.1053/j.ajkd.2015.11. 021.
| Schlagworte: | GSK1278863 |
| Anwendung: | Targets hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29] (EGLN, HPH) |
| CAS | 960539-70-2 |
| MW: | 393.43 D |
ab 30,00 €
Roxadustat
Artikelnummer: Cay15294-10
Roxadustat is an analog of 2-OG that has been developed as an inhibitor of HIF-PHs. While little has been published regarding the actions of this compound, similar HIF-PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression, promoting erythropoiesis or preventing anemia in vivo.Formal...
| Schlagworte: | ASP1517, Roxadustat, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-glycine |
| Anwendung: | Presumed HIF-PH inhibitor |
| CAS | 808118-40-3 |
| MW: | 352.4 D |
ab 40,00 €
EGLN2 Protein, Human, Recombinant (His & SUMO)
Artikelnummer: TGM-TMPH-03905-100ug
Description: EGLN2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli with N-6xHis-SUMO. The accession number is Q96KS0.
| Schlagworte: | HPH-3 , Hypoxia-inducible factor prolyl hydroxylase 1 (HIF-PH1,HIF-prolyl hydroxylase 1,HPH-1) , Prolyl hydroxylase EGLN2... |
| MW: | 32.3 kD |
ab 71,00 €
EGLN3 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-03906-100ug
Description: EGLN3 Protein, Human, Recombinant (His) is expressed in E. coli with C-6xHis. The accession number is Q9H6Z9.
| Schlagworte: | Hypoxia-inducible factor prolyl hydroxylase 3 (HIF-PH3,HIF-prolyl hydroxylase 3,HPH-3) , Prolyl hydroxylase... |
| MW: | 34.1 kD |
ab 93,00 €
EGLN1 Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-04656-100ug
Description: EGLN1 Protein, Human, Recombinant (His) is expressed in E. coli. The accession number is Q9GZT9.
| Schlagworte: | Egl nine homolog 1 , EGLN1 , C1orf12 , Prolyl hydroxylase domain-containing protein 2 (PHD2) , Hypoxia-inducible factor... |
| MW: | 31.9 kD |
ab 109,00 €
Adaptaquin-d4
Artikelnummer: Cay9004909-1
Adaptaquin-d4 is intended for use as an internal standard for the quantification of adaptaquin (Cay-19720) by GC- or LC-MS. Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2. IC50 = 2 µM). It stabilizes HIF-1alpha protein and induces expression of the HIF-1-regulated genes EPO and...
| Schlagworte: | 7-((4-chlorophenyl-2,3,5,6-d4)((3-hydroxypyridin-2-yl)amino)methyl)quinolin-8-ol |
| Anwendung: | GC-MS, LC-MS internal standard, quantification, HIF-PH2 inhibitor |
| MW: | 381.85 D |
260,00 €
Vadadustat
Artikelnummer: Cay15295-5
Vadadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and HIF-PH3 (IC50s = 1.1 and 0.39 micromolar, respectively). It stabilizes HIF-1alpha in mouse hepatocyte nuclear extracts. Vadadustat (50 and 100 mg/kg) increases erythropoietin levels in mouse serum.Formal Name:...
| Schlagworte: | AKB6548, PG-1016548, N-[[5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-glycine |
| Anwendung: | PHD2 / PHD3 inhibitor |
| CAS | 1000025-07-9 |
| MW: | 306.7 D |
ab 97,00 €
BAY 85-3934
Artikelnummer: Cay15297-5
BAY 85-3934 is a pan-inhibitor of hypoxia-inducible factor prolyl hydroxylases (HIF-PH, IC50s = 0.48, 0.28, and 0.45 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It stabilizes HIF-1alpha and HIF-2alpha levels in HeLa cells in a concentration- and time-dependent manner. BAY 85-3934 (50 µM) induces cell-cycle...
| Schlagworte: | Molidustat, 1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-3H-pyrazol-3-one |
| Anwendung: | HIF-1alpha prolyl hydroxylase inhibitor |
| CAS | 1154028-82-6 |
| MW: | 314.3 D |
ab 53,00 €