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Zu "K09592" wurden 95 Artikel gefunden!
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Artikelnummer: Cay15294-10
Roxadustat is an analog of 2-OG that has been developed as an inhibitor of HIF-PHs. While little has been published regarding the actions of this compound, similar HIF-PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression, promoting erythropoiesis or preventing anemia in vivo.Formal...
Schlagworte: | ASP1517, Roxadustat, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-glycine |
Anwendung: | Presumed HIF-PH inhibitor |
CAS | 808118-40-3 |
MW: | 352.4 D |
ab 43,00 €
Artikelnummer: ELK-ELK7994.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse EGLN1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse EGLN1. Next,...
Schlagworte: | PHD2, SM-20, Egln1, HPH-2, HIF-PH2, Egl nine homolog 1, HIF-prolyl hydroxylase 2, Hypoxia-inducible factor prolyl... |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
ab 365,00 €
Artikelnummer: ELK-ELK7299.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human EGLN1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human EGLN1. Next,...
Schlagworte: | PHD2, SM-20, HPH-2, C1orf12, HIF-PH2, PNAS-118, Egl nine homolog 1, HIF-prolyl hydroxylase 2, Hypoxia-inducible factor... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: Cay15297-5
BAY 85-3934 is a pan-inhibitor of hypoxia-inducible factor prolyl hydroxylases (HIF-PH, IC50s = 0.48, 0.28, and 0.45 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It stabilizes HIF-1alpha and HIF-2alpha levels in HeLa cells in a concentration- and time-dependent manner. BAY 85-3934 (50 µM) induces cell-cycle...
Schlagworte: | Molidustat, 1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-3H-pyrazol-3-one |
Anwendung: | HIF-1alpha prolyl hydroxylase inhibitor |
CAS | 1154028-82-6 |
MW: | 314.3 D |
ab 44,00 €
Artikelnummer: Cay15295-5
Vadadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and HIF-PH3 (IC50s = 1.1 and 0.39 micromolar, respectively). It stabilizes HIF-1alpha in mouse hepatocyte nuclear extracts. Vadadustat (50 and 100 mg/kg) increases erythropoietin levels in mouse serum.Formal Name:...
Schlagworte: | AKB6548, PG-1016548, N-[[5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-glycine |
Anwendung: | PHD2 / PHD3 inhibitor |
CAS | 1000025-07-9 |
MW: | 306.7 D |
ab 84,00 €
Artikelnummer: Cay16021-100
Ciclopirox is an iron chelator, antifungal, and anticancer agent. It inhibits the iron-dependent enzyme hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2, IC50 = 1.58 µM), an effect that is reduced in the presence of iron. It stabilizes hypoxia-inducible factor-alpha (HIF-1alpha) under normoxic conditions in...
Schlagworte: | HOE 296b, 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone |
Anwendung: | Antifungal, Cell-permeable iron-chelating agent, EGLN1 inhibitor |
CAS | 29342-05-0 |
MW: | 207.3 D |
ab 109,00 €
Artikelnummer: Cay19915-5
Daprodustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 1 (HIF-PH1), HIF-PH2, and HIF-PH3 (IC50s = 3.5, 22.2, 5.5 nM, respectively). It is selective for HIF-PH1, -2, and -3 over factor-inhibiting HIF (FIH) and collagen prolyl hydroxylase (CP4H, IC50s = 9,800 and >200,000 nM, respectively)....
Schlagworte: | GSK1278863, N-[(1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]-glycine |
Anwendung: | HIF-prolyl hydroxylase inhibitor |
CAS | 960539-70-2 |
MW: | 393.4 D |
ab 43,00 €
Artikelnummer: A300-327A
Protein function: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal,...
Schlagworte: | Anti-PHD3, Anti-HPH-3, Anti-EGLN3, Anti-HPH-1, Anti-HIF-PH3, EC=1.14.11.29, Anti-Egl nine homolog 3, Anti-HIF-prolyl... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse |
ab 164,00 €
Artikelnummer: Cay18382-5
FG-2216 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2, IC50 = 3.9 micromolar). It has been shown to reversibly stimulate erythropoietin secretion at 100 µM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.Formal Name:...
Schlagworte: | IOX3, YM-311, N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-glycine |
Anwendung: | HIF-prolyl hydroxylase inhibitor |
CAS | 223387-75-5 |
MW: | 280.7 D |
ab 60,00 €
Artikelnummer: A300-322A
Protein function: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal,...
Schlagworte: | Anti-PHD2, Anti-HPH-2, Anti-SM-20, Anti-HIF-PH2, Anti-C1orf12, Anti-PNAS-118, Anti-Egl nine homolog 1, Anti-HIF-prolyl... |
Anwendung: | WB, IP |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: Cay18181-5
IOX4 is a potent inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2, IC50 = 1.6 nM). It displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases, including JMJD isoforms, FBXL11, JARID1C, BBOX1, FIH, and FTO. IOX4 is active in vivo, inhibiting prolyl hydroxylation and...
Schlagworte: | 1,1-dimethylethyl ester 6-[2,5-dihydro-5-oxo-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]-3-pyridinecarboxylic acid |
Anwendung: | HIF-PH2 inhibitor |
CAS | 1154097-71-8 |
MW: | 328.3 D |
ab 98,00 €
Artikelnummer: Cay28074-10
Desidustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH). It reduces levels of hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor regulated by HIF-PH enzymes, in rat liver and kidney. Desidustat increases the expression of the red blood cell- and iron transport-related...
Schlagworte: | N-[[1-(cyclopropylmethoxy)-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl]carbonyl]-glycine |
Anwendung: | PHD (Prolyl hydroxylase domain-containing protein) inhibitor |
CAS | 1616690-16-4 |
MW: | 332.3 D |
ab 195,00 €