AZD 5597

AZD 5597 is a cyclin-dependent kinase 1 (Cdk1) and Cdk2 inhibitor (IC50 = 0.002 µM for both). It inhibits LoVo cell proliferation (IC50 = 0.039 µM). In vivo, AZD 5597 (15 mg/kg) reduces tumor volume in an SW620 colon adenocarcinoma mouse xenograft model.Formal Name: [4-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-2-pyrimidinyl]amino]phenyl][(3S)-3-(methylamino)-1-pyrrolidinyl]-methanone. CAS Number: 924641-59-8. Molecular Formula: C23H28FN7O. Formula Weight: 437.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: FC1=CN=C(N=C1C2=CN=C(N2C(C)C)C)NC3=CC=C(C(N4CC[C@H](NC)C4)=O)C=C3. InChi Code: InChI=1S/C23H28FN7O/c1-14(2)31-15(3)26-12-20(31)21-19(24)11-27-23(29-21)28-17-7-5-16(6-8-17)22(32)30-10-9-18(13-30)25-4/h5-8,11-12,14,18,25H,9-10,13H2,1-4H3,(H,27,28,29)/t18-/m0/s1. InChi Key: NTSDIJMNXYJJNG-SFHVURJKSA-N.