AZ 7550 (hydrochloride)

AZ 7550 is an active metabolite of AZ 9291 (Cay-16237). It inhibits the insulin-like growth factor 1 receptor (IGF-1R) in a cell-free assay (IC50 = 1.6 µM). It inhibits EGFR autophosphorylation in H1975 and PC-9 cells expressing the respective constitutively active mutants EGFRT790M/L858R and EGFRExon19del (IC50s = 0.045 and 0.026 µM, respectively), as well as in LoVo cells expressing wild-type EGFR (IC50 = 0.786 µM).Formal Name: N-[4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-2-propenamide, hydrochloride. Molecular Formula: C27H31N7O2 . XHCl. Formula Weight: 485.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble, Methanol: Soluble. SMILES: O=C(NC1=CC(NC2=NC(C3=CN(C)C4=C3C=CC=C4)=CC=N2)=C(C=C1N(CCNC)C)OC)C=C.Cl. InChi Code: InChI=1S/C27H31N7O2.ClH/c1-6-26(35)30-21-15-22(25(36-5)16-24(21)33(3)14-13-28-2)32-27-29-12-11-20(31-27)19-17-34(4)23-10-8-7-9-18(19)23,/h6-12,15-17,28H,1,13-14H2,2-5H3,(H,30,35)(H,29,31,32),1H. InChi Key: BHYPVGSNUFXTCM-UHFFFAOYSA-N.