AZ 33

AZ 33 is an inhibitor of lactate dehydrogenase A (LDHA, Kd = 0.093 µM, IC50 = 0.5 µM). It is selective for LDHA over LDHB in an NADH competition assay using recombinant enzymes (IC50s = 0.54 and 3.6 µM, respectively). AZ 33 is cell-impermeable and lacks cytotoxicity against HeLa cervical cancer cells (IC50 = >500 µM).Formal Name: 2-[[4-[4-[[3-[(2-methyl-6-benzothiazolyl)amino]-3-oxopropyl]amino]-4-oxobutyl]phenyl]methyl]-propanedioic acid. CAS Number: 1370290-34-8. Molecular Formula: C25H27N3O6S. Formula Weight: 497.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30mg/mL, DMSO: 30mg/mL, Ethanol: 2mg/mL, PBS (pH 7.2): slight. lambdamax: 223, 280 nm. SMILES: OC(C(C(O)=O)CC1=CC=C(CCCC(NCCC(NC2=CC=C(N=C(C)S3)C3=C2)=O)=O)C=C1)=O. InChi Code: InChI=1S/C25H27N3O6S/c1-15-27-20-10-9-18(14-21(20)35-15)28-23(30)11-12-26-22(29)4-2-3-16-5-7-17(8-6-16)13-19(24(31)32)25(33)34/h5-10,14,19H,2-4,11-13H2,1H3,(H,26,29)(H,28,30)(H,31,32)(H,33,34). InChi Key: SGFJAJFBGVAOFW-UHFFFAOYSA-N.