Asterric Acid

Asterric acid is an antibiotic fungal metabolite that completely inhibits the binding of the potent vasoconstrictor endothelin (ET)-1 to the ETA receptor in A10 cells at 0.1 µM. Asterric acid derivatives have also been shown to inhibit VEGF-induced tube formation of human umbilical vein endothelial cells at 3-10 µM, which suggests its usefulness as an antiangiogenic agent.Formal Name: 2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxy-benzoic acid, 1-methyl ester. CAS Number: 577-64-0. Synonyms: Dimethylosoic Acid, RES-1214-1, TAN 1415A. Molecular Formula: C17H16O8. Formula Weight: 348.3. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. lambdamax: 214, 252, 315 nm. SMILES: CC1=CC(O)=C(C(O)=O)C(OC2=C(OC)C=C(O)C=C2C(OC)=O)=C1. InChi Code: InChI=1S/C17H16O8/c1-8-4-11(19)14(16(20)21)12(5-8)25-15-10(17(22)24-3)6-9(18)7-13(15)23-2/h4-7,18-19H,1-3H3,(H,20,21). InChi Key: XOKVHFNTYHPEHN-UHFFFAOYSA-N. Origin: Fungus/Aspergillus terreus.