Zu "K04197" wurden 66 Artikel gefunden!
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CHO-K1/EDNRA Stable Cell Line
Artikelnummer: GSC-M00149
In mammals, the endothelin (ET) family comprises three endogenous isoforms: ET-1, ET-2, and ET-3. These endothelium-derived peptides perform their functions via two endothelin receptors, classified as EDNRA and EDNRB. EDNRA receptors are mainly localized in the vascular smooth muscle cells, where they are the...
| Schlagworte: | EDNRA, Endothelin-1 receptor, Endothelin receptor type A |
11.424,00 €
Ambrisentan
Artikelnummer: TGM-T1655-5mg
Description: Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but has yet to be implicated in cases of clinically apparent acute liver injury. Target:...
| Schlagworte: | BSF 208075, BSF-208075, LU 208075 |
| Anwendung: | Targets endothelin receptor type A (EDNRA) |
| CAS | 177036-94-1 |
| MW: | 378.42 D |
ab 30,00 €
BQ-123 sodium salt
Artikelnummer: AG-CP3-0001-M001
Potent and selective endothelin receptor A (ETA) antagonist, suppresses the ET-1-induced decrease of LPL activity, shows protective effects in ischemic acute renal failure, neuroprotective, anti-hypertensive, inhibits ET-1 receptor binding and blocks Ca2 mobilization, cellular contraction and MAP kinase activation,...
| Schlagworte: | Endothelin Receptor A Antagonist BQ-123, cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu) Na |
| Anwendung: | Endothelin receptor A antagonist |
| CAS | 136553-81-6 |
| MW: | 609,7 D |
ab 116,00 €
Macitentan
Artikelnummer: Cay23304-100
Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively). Macitentan inhibits intracellular Ca2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells...
| Schlagworte: | ACT-064992, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-sulfamide |
| Anwendung: | Dual EDNRA / EDNRB antagonist |
| CAS | 441798-33-0 |
| MW: | 588.3 D |
ab 58,00 €
Ambrisentan
Artikelnummer: Cay23669-5
Ambrisentan is a nonpeptide endothelin A (ETA) receptor antagonist (IC50s = 0.251, 0.316, 0.398, 251, and 630 nM for rat preparations of heart, bladder, kidney, lung, and cerebral cortex, respectively). It inhibits contraction of isolated rabbit aortic rings induced by endothelin-1 (ET-1, Cay-24127) by 43.23% when...
| Schlagworte: | alphaS-[(4,6-dimethyl-2-pyrimidinyl)oxy]-beta-methoxy-beta-phenyl-benzenepropanoic acid |
| Anwendung: | Endothelin A (ETA) receptor antagonist |
| CAS | 177036-94-1 |
| MW: | 378.4 D |
ab 49,00 €
Sitaxentan (sodium salt)
Artikelnummer: Cay29244-5
Sitaxentan is a potent nonpeptide endothelin A (ETA) receptor antagonist (IC50 = 1.4 nM). It is selective for ETA over ETB receptors (IC50 = 9,800 nM). Sitaxentan inhibits phosphoinositol hydrolysis induced by endothelin-1 (Cay-24127) in COS-7 cells (pA2 = 8). In vivo, sitaxentan reduces blood pressure in a rat...
| Schlagworte: | TBC 11251, Thelin, N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonamide,... |
| Anwendung: | Potent endothelin A receptor antagonist |
| CAS | 210421-74-2 |
| MW: | 476.9 D |
ab 68,00 €
Bosentan-d4
Artikelnummer: Cay22097-25
Bosentan-d4 is an internal standard for the quantification of bosentan (Cay-11731) by GC- or LC-MS. Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM).Formal Name:...
| Schlagworte: | 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy-1,1,2,2-d4)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide |
| Anwendung: | GC-MS, LC-MS, internal standard |
| CAS | 1065472-77-6 |
| MW: | 555.6 D |
ab 409,00 €
Human ETRA / Endothelin A Receptor ELISA Kit
Artikelnummer: G-HUFI02432.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Kendomycin
Artikelnummer: BVT-0001-C100
Antibiotic, Potent endothelin receptor antagonist, Anti-osteoporotic, Antibacterial, Cytotoxic, Mediates its cytotoxic effects, at least in part, through proteasome inhibition. Isolated from Streptomyces violaceoruber.
| Schlagworte: | (-)-TAN 2162 |
| Anwendung: | Endothelin receptor antagonist |
| CAS | 183202-73-5 |
| MW: | 486,6 D |
ab 95,00 €
Zibotentan
Artikelnummer: Cay23702-1
Zibotentan is a selective antagonist of the endothelin (ET) receptor type A (IC50s = 21 and >10,000 nM for human recombinant ETA and ETB, respectively). It inhibits growth of HEY, OVCA 433, SKOV3, and A2780 cells induced by endothelin 1 (ET-1, Cay-24127) in vitro. Zibotentan reduces ET-1-induced expression of MMP-2,...
| Schlagworte: | ZD 4054, N-(3-methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide |
| Anwendung: | Antineoplastic, endothelin receptor type A antagonist |
| CAS | 186497-07-4 |
| MW: | 424.4 D |
ab 49,00 €
Kendomycin
Artikelnummer: LKT-K1653.100
Macrolide, ET antagonist, proteasome inhibitor.
| Schlagworte: | (-)-TAN 2162 |
| Anwendung: | Macrolide, ET antagonist, proteasome inhibitor |
| CAS | 183202-73-5 |
| MW: | 486.64 D |
ab 225,00 €
Macitentan
Artikelnummer: LKT-M0009.25
Macitentan is a dual endothelin receptor (ET-A/B)antagonist that displays antihypertensive, anti-fibrotic, and anticancer activity, this compound exhibits slower receptor dissociation kinetics than other endothelin receptor antagonists. Macitentan is currently used to treat pulmonary arterial hypertension, as...
| Schlagworte: | ACT-064992, Actelion-1 |
| Anwendung: | Endothelin receptor type A antagonist, Endothelin receptor type B antagonist |
| CAS | 441798-33-0 |
| MW: | 588.27 D |
ab 73,00 €