Asoxime (chloride)

Organophosphates inactivate acetylcholinesterase (AChE) by reacting covalently with the active center serine, thus inhibiting its action of hydrolyzing acetylcholine at central and peripheral synapses. Acetylcholine accumulation results in an over-stimulation of cholinergic receptors, which can disrupt numerous biological functions. Asoxime is an asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates. It demonstrates therapeutic activity in experimental models of organophosphate poisoning, by reactivating phosphorylated AChE that was inhibited as a result of exposure to various cytotoxic nerve agents.Formal Name: 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium, dichloride. CAS Number: 34433-31-3. Synonyms: HI-6. Molecular Formula: C14H16N4O3 . 2Cl. Formula Weight: 359.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/mL. lambdamax: 217, 300 nm. SMILES: O/N=C\C1=CC=CC=[N+]1COC[N+]2=CC=C(C(N)=O)C=C2.[Cl-].[Cl-]. InChi Code: InChI=1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20,,/h1-9H,10-11H2,(H-,15,19),2*1H. InChi Key: QELSIJXWEROXOE-UHFFFAOYSA-N.