AS-1269574

GPR119, a glucose-dependent insulinotropic receptor, is a Gs protein-coupled receptor that is expressed in pancreas beta-cells and intestinal L-cells. Activation of GPR119 by the endogenous ligands lyso-phosphatidylcholine and oleoyl ethanolamide increases intracellular cAMP levels and promotes glucose-stimulated insulin secretion. AS-1269574 is an agonist of GPR119 that is effective both in isolated cells and in vivo. It increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 µM) and glucose-stimulated insulin secretion in mice (100 mg/kg).Formal Name: 2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]-ethanol. CAS Number: 330981-72-1. Molecular Formula: C13H14BrN3O. Formula Weight: 308.2. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7) (1:10): 0.1 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 253 nm. SMILES: BrC(C=C1)=CC=C1C2=NC(NCCO)=CC(C)=N2. InChi Code: InChI=1S/C13H14BrN3O/c1-9-8-12(15-6-7-18)17-13(16-9)10-2-4-11(14)5-3-10/h2-5,8,18H,6-7H2,1H3,(H,15,16,17). InChi Key: DUKPGOOUJNUIOI-UHFFFAOYSA-N.