Anacardic Acid

Anacardic acid, isolated from cashew shells or several other medicinal plants, is the general name given to a family of four different 6-alkyl salicyclic acids having varying degrees of unsaturation in the 15-carbon alkyl chain. These compounds are associated with anti-inflammatory, anti-tumor, molluscicidal, and anti-microbial activity. Literature frequently sites and gives the name anacardic acid to the completely-saturated compound (6-pentadecyl salicylic acid). Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (PCAF) with IC50 values of 8.5 and 5 µM, respectively. At 25 µmol/L, anacardic acid suppresses NF-kappaB activation, inhibits IkappaB-alpha phosphorylation, and prohibits p65 nuclear translocation in KBM-5 cells.Formal Name: 2-hydroxy-6-pentadecyl-benzoic acid. CAS Number: 16611-84-0. Synonyms: 6-pentadecyl Salicylic Acid. Molecular Formula: C22H36O3. Formula Weight: 348.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 15 mg/ml, Ethanol: 22 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 209, 243, 312 nm. SMILES: CCCCCCCCCCCCCCCc1cccc(O)c1C(=O)O. InChi Code: InChI=1S/C22H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h15,17-18,23H,2-14,16H2,1H3,(H,24,25). InChi Key: ADFWQBGTDJIESE-UHFFFAOYSA-N.