Akt Inhibitor X

Akt functions as a key component in multiple signaling pathways to promote cell survival by mediating resistance to apoptosis. Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt with an IC50 value of 1-2 µM. This compound has been shown to block IGF-1-stimulated nuclear translocation of Akt in Rh1 cells and to inhibit the growth of Rh1, Rh18, and Rh30 cells with IC50 values of 2-5 µM. Inhibition of Akt phosphorylation by 5 µM of this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.Formal Name: 2-chloro-N,N-diethyl-10H-phenoxazine-10-butanamine, monohydrochloride. CAS Number: 925681-41-0. Synonyms: 10-DEBC. Molecular Formula: C20H25ClN2O . HCl. Formula Weight: 381.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 12.5 mg/ml, Ethanol: 16 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 242, 333 nm. SMILES: ClC1=CC2=C(C=C1)OC3=CC=CC=C3N2CCCCN(CC)CC.Cl. InChi Code: InChI=1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23,/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3,1H. InChi Key: SVKSJUIYYCQZEC-UHFFFAOYSA-N.