9-cis-Retinoic Acid

9-cis-Retinoic acid is a natural metabolite of vitamin A, derived from the intermediate all-trans retinoic acid (Cay-11017). It potently activates all isoforms of retinoic acid receptor (RAR) (Ki = 0.5-27 nM) as well as retinoid X receptor (RXR) isoforms (Ki = 3.8-12 nM). RAR heterodimerizes with RXR, while RXR can homodimerize as well as heterodimerize with numerous partners in addition to RAR, thus allowing 9-cis-retinoic acid to evoke a wide range of effects.Formal Name: 9-cis-retinoic acid. CAS Number: 5300-03-8. Synonyms: Alitretinoin, NSC 659772, Panretin, 9-cis RA. Molecular Formula: C20H28O2. Formula Weight: 300.4. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 242, 348, 357 nm. SMILES: CC1(C)C(/C=C/C(C)=C\C=C\C(C)=C\C(O)=O)=C(C)CCC1. InChi Code: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+. InChi Key: SHGAZHPCJJPHSC-ZVCIMWCZSA-N.