Zu "K08527" wurden 86 Artikel gefunden!
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9-cis-Retinoic Acid
Artikelnummer: Cay14587-1
9-cis-Retinoic acid is a natural metabolite of vitamin A, derived from the intermediate all-trans retinoic acid (Cay-11017). It potently activates all isoforms of retinoic acid receptor (RAR) (Ki = 0.5-27 nM) as well as retinoid X receptor (RXR) isoforms (Ki = 3.8-12 nM). RAR heterodimerizes with RXR, while RXR can...
| Schlagworte: | Alitretinoin, 9-cis RA, NSC 659772, Panretin, 9-cis-retinoic acid |
| Anwendung: | RAR and RXR activator |
| CAS | 5300-03-8 |
| MW: | 300.4 D |
ab 73,00 €
TTNPB
Artikelnummer: Cay16144-1
TTNPB is an analog of retinoic acid (Cay-11017) that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARalpha, RARbeta, and RARgamma, respectively). It does not act on retinoid X receptors and weakly agonizes farnesoid X receptor (EC50 > 1 µM). TTNPB is used to study RAR...
| Schlagworte: | AGN 191183, Arotinoid Acid, Ro 13-7410,... |
| Anwendung: | Retinoic acid receptor agonist |
| CAS | 71441-28-6 |
| MW: | 348.5 D |
ab 67,00 €
AM580
Artikelnummer: Cay15261-1
AM580 is a retinoic acid receptor agonist that is selective for RARalpha (Kd = 8 nM, AC50 = 0.36 nM) compared to RARbeta (Kd = 131 nM, AC50 = 24.6 nM) and RARgamma (Kd = 450 nM, AC50 = 27.9 nM). It demonstrates greater specific binding to RARalpha compared to retinoic acid (Cay-11017), which exhibits little...
| Schlagworte: | CD336, NSC 608001, Ro 40-6055, 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]-benzoic acid |
| Anwendung: | RAR alpha (retinoic acid receptor alpha) agonist |
| CAS | 102121-60-8 |
| MW: | 351.4 D |
ab 49,00 €
all-trans Retinoic Acid
Artikelnummer: Cay11017-500
all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARalpha, RARbeta, and RARgamma, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARalpha, RARbeta, or...
| Schlagworte: | atRA, NSC 122578, NSC 122758, RA, Vitamin A Acid,... |
| Anwendung: | RAR / RXR ligand |
| CAS | 302-79-4 |
| MW: | 300.4 D |
ab 54,00 €
4-oxo Isotretinoin
Artikelnummer: Cay34388-10
4-oxo Isotretinoin is an active metabolite of the retinoid isotretinoin (Cay-21648). It is formed from isotretinoin by several cytochrome P450 (CYP450) isoforms, including CYP3A, CYP2B6, and CYP2C19. 4-oxo Isotretinoin (10 µM) increases protein expression of cytokeratin 7 (CK7) and CK19 in normal human epidermal...
| Schlagworte: | Ro 22-6595, 13-cis-4-oxo-retinoic acid |
| Anwendung: | Active isotretinoin metabolite |
| CAS | 71748-58-8 |
| MW: | 314.4 D |
ab 60,00 €
RARalpha Reporter Cell Line (2x10(6) cells)
Artikelnummer: BPS-60503
2x10(6) cells. The RARalpha Reporter (Luc)-HEK293 Cell Line is designed for monitoring the activity of retinoic acid receptor alpha (RARalpha). The RARalpha Reporter (Luc)-HEK293 Cell Line contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells...
| Schlagworte: | RARA, NR1B1, RAR-alpha, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1, |
| Anwendung: | RARalpha reporter assays |
| Wirt: | Human cells |
| Spezies-Reaktivität: | human |
3.492,00 €
RARalpha (human) Reporter Assay Kit
Artikelnummer: IB-IB02201
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, alpha (NR1B1), a ligand-dependent transcription factor commonly referred to as RARA or RARalpha. INDIGO's reporter cells include the luciferase...
| Schlagworte: | RARA, NR1B1, RAR-alpha, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.588,00 €
all-trans Retinoic Acid-d5
Artikelnummer: Cay25415-1
all-trans Retinoic acid-d5 is intended for use as an internal standard for the quantification of all-trans retinoic acid (Cay-11017) by GC- or LC-MS. all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARalpha, RARbeta, and...
| Schlagworte: | atRA-d5, RA-d5, Vitamin A Acid-d5,... |
| Anwendung: | RAR / RXR ligand, protein synthesis inhibitor, GC-MS, LC-MS, internal standard |
| MW: | 305.5 D |
ab 318,00 €
BMS 195614
Artikelnummer: Cay16029-1
BMS 195614 is a neutral retinoic acid receptor (RAR) alpha-selective antagonist (Ki = 2.5 nM). It antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR but does not significantly affect nuclear receptor corepressor binding.Formal Name:...
| Schlagworte: | BMS 614, 4-[[[5,6-dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]-benzoic acid |
| Anwendung: | RARA antagonist |
| CAS | 182135-66-6 |
| MW: | 448.5 D |
ab 44,00 €
Ch 55
Artikelnummer: Cay18658-5
Ch 55 is a synthetic analog of retinoic acid (Cay-11017) that binds to retinoic acid receptors with similar efficiency as retinoic acid (Kis in the nM range) yet does not display affinity for cellular retinoic acid-binding protein (Ki = 540 µM). Ch 55 has been shown to inhibit squamous cell differentiation of rabbit...
| Schlagworte: | 4-[(1E)-3-[3,5-bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propen-1-yl]-benzoic acid |
| Anwendung: | Retinoic acid receptor ligand |
| CAS | 110368-33-7 |
| MW: | 364.5 D |
ab 56,00 €
BMS 753
Artikelnummer: Cay29493-1
BMS 753 is a synthetic retinoid and retinoic acid receptor alpha (RARalpha) agonist (Ki = 2 nM). It is selective for RARalpha over RARgamma at 1 µM. BMS 753 (10 and 100 nM) induces morphological differentiation of P19 embryonal carcinoma cells, as well as F9 embryonal carcinoma cells when used at a concentration of...
| Schlagworte: | 4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid |
| Anwendung: | Synthetic retinoid, RARalpha agonist |
| CAS | 215307-86-1 |
| MW: | 351.4 D |
ab 49,00 €
BMS 453
Artikelnummer: Cay19076-1
Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation. BMS 453 is a synthetic retinoid that acts as an agonist of RARbeta and an antagonist of RARalpha and RARgamma. It has been shown to inhibit the proliferation of normal breast cells via the...
| Schlagworte: | BMS 189453, 4-[(1E)-2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl], benzoic acid |
| Anwendung: | RARbeta agonist, RARalpha / RARgamma antagonist |
| CAS | 166977-43-1 |
| MW: | 380.5 D |
ab 56,00 €