Human PIEZO1 (Piezo-type mechanosensitive ion channel component 1) ELISA Kit (HUFI04961)

Human PIEZO1 (Piezo-type mechanosensitive ion channel component 1) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human PIEZO1 (Piezo-type mechanosensitive ion channel component 1) in serum, plasma & cell culture supernatant samples. The Human PIEZO1 (Piezo-type mechanosensitive ion channel component 1) ELISA Kit accurately measures natural Human PIEZO1 (Piezo-type mechanosensitive ion channel component 1) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human PIEZO1 (Piezo-type mechanosensitive ion channel component 1) peptide. Protein function: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R- Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. [The UniProt Consortium]