Human Kallistatin - Serpina4 ELISA Kit

Human Kallistatin - Serpina4 ELISA Kit
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
KOA0502 1 kit - -

1 - 9 Werktage

728,00 €
 
Natural and recombinant human Kallistatin. There is no detectable cross-reactivity with other... mehr
Produktinformationen "Human Kallistatin - Serpina4 ELISA Kit"
Natural and recombinant human Kallistatin. There is no detectable cross-reactivity with other relevant proteins. Protein function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. [The UniProt Consortium]
Schlagworte: PBT, KIT, SCFR, CD117, p145 c-kit, EC=2.7.10.1, Proto-oncogene c-Kit, Piebald trait protein, Tyrosine-protein kinase Kit, Mast/stem cell growth factor receptor Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Hersteller: Rockland Immunochemicals
Hersteller-Nr: KOA0502

Eigenschaften

Anwendung: ELISA
Wirt: Human
Reaktivität: Human
Immunogen: Expression system for standard: NSO, Immunogen sequence: Q21-P427
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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