Anti-HMGB1, clone 1F3

Aktion:

Gratis WB-Box zu jeder Arigo-Bestellung. 

*1
*1 Angebot gültig bis zum 30.04.2019
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ARG10756.50 50 µl - -

6 - 14 Werktage

439,00 €
 
Protein function: Multifunctional redox sensitive protein with various roles in different... mehr
Produktinformationen "Anti-HMGB1, clone 1F3"
Protein function: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). [The UniProt Consortium]
Schlagworte: Anti-HMG1, Anti-HMGB1, Anti-HMG-1, Anti-High mobility group protein 1, Anti-High mobility group protein B1
Hersteller-Nr: ARG10756050

Eigenschaften

Anwendung: WB, ICC, IF, IHC
Antikörper-Typ: Monoclonal
Klon: 1F3
Wirt: Mouse
Reaktivität: Human
Immunogen: Human full length protein expressed and purified form E. coli
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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