Anti-HMGB1

Anti-HMGB1 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. HMGB1 antibody is human, mouse and rat reactive. Protein function: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. [The UniProt Consortium]