Anti-HER-2, clone 1423CT594.76.52

Anti-HER-2, clone 1423CT594.76.52
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-F52968-0.08ML 80 µl - -

3 - 10 Werktage*

326,00 €
NSJ-F52968-0.4ML 400 µl - -

3 - 10 Werktage*

702,00 €
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Protein tyrosine kinase that is part of several cell... mehr
Produktinformationen "Anti-HER-2, clone 1423CT594.76.52"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Protein function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. [The UniProt Consortium]
Schlagworte: Anti-HER2, Anti-CD340, Anti-ERBB2, Anti-MLN 19, Anti-p185erbB2, EC=2.7.10.1, Anti-Proto-oncogene Neu, Anti-Proto-oncogene c-ErbB-2, Anti-Metastatic lymph node gene 19 protein, Anti-Receptor tyrosine-protein kinase erbB-2, HER-2 Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: F52968

Eigenschaften

Anwendung: WB, ELISA
Antikörper-Typ: Monoclonal
Klon: 1423CT594.76.52
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: This HER-2 antibody was produced from a mouse immunized with a recombinant protein.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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