Zu "K05083" wurden 573 Artikel gefunden!
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NEU
Zongertinib
Artikelnummer: Cay44994-10
Zongertinib is an inhibitor of mutant HER2 containing an activating exon 20 insertion (HER2YVMA. IC50 = 13 nM in a cellular phosphorylation assay using HEK cells). It is selective for the inhibition of HER2YVMA over wild-type EGFR (IC50 = 576 nM in a cellular phosphorylation assay using HEK cells). It is also...
| Schlagworte: | BI 1810631,... |
| Anwendung: | HER2-YVMA inhibitor |
| CAS | 2728667-27-2 |
| MW: | 535.61 D |
ab 134,00 €
NEU
Trastuzumab (Anti-HER2 Antibody)
Artikelnummer: BPS-83967-1
Trastuzumab is a humanized IgG1 recombinantmonoclonal antibody that selectively binds to HER2 (eceptor tyrosine-protein kinase ErbB-2) with high affinity. Trastuzumab can be used for the research of HER2-positive metastatic breast and gastric cancer. Trastuzumab consists of two antigen-specific sites that bind to...
| Schlagworte: | ERBB2, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Proto-oncogene... |
| Anwendung: | ELISA, FC, FA |
| Wirt: | Human |
| Spezies-Reaktivität: | human |
| CAS | 180288-69-1 |
ab 560,00 €
Anti-Recombinant Phospho-HER2 (Tyr1221, 1222), clone 1F12
Artikelnummer: E-AN300660L.100
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer,...
| Schlagworte: | Anti-ERBB2, Anti-p185erbB2, Anti-Proto-oncogene Neu, Anti-Proto-oncogene c-ErbB-2, Anti-Metastatic lymph node gene 19... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 258,00 €
Anti-Recombinant HER2, clone 6H3
Artikelnummer: E-AN300730L.100
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer,...
| Schlagworte: | Anti-ERBB2, Anti-p185erbB2, Anti-Proto-oncogene Neu, Anti-Proto-oncogene c-ErbB-2, Anti-Metastatic lymph node gene 19... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-phospho-ErbB2 (Tyr1221/Tyr1222) / HER2 / NEU, clone...
Artikelnummer: NSJ-FY12766
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-ErbB2 (Tyr1221/Tyr1222) antibody detects ErbB2, encoded by the ERBB2 gene, when phosphorylated at tyrosines 1221 and 1222. ErbB2 is also commonly called HER2, NEU, proto oncogene Neu, and...
| Schlagworte: | Anti-phospho-ERBB2, Anti-phospho-p185erbB2, Anti-phospho-Proto-oncogene Neu, Anti-phospho-Proto-oncogene c-ErbB-2,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Human HER2 / ErbB2 ELISA Kit
Artikelnummer: ARG81734.96
Protein function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor....
| Schlagworte: | HER2, CD340, ERBB2, MLN 19, p185erbB2, EC=2.7.10.1, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Metastatic lymph node... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
1.118,00 €
Her2, Avi & His, Human
Artikelnummer: GSC-Z03806-100
ErbB2, also known as Neu and Her2, is a type I membrane glycoprotein belonging to the ErbB family of tyrosine kinase receptors. It serves as a receptor for the epidermal growth factor (EGF) family of growth factors. Upon activation, ERBB2 triggers the MEMO1-RHOA-DIAPH1 signaling pathway, leading to the...
| Schlagworte: | ERBB2, p185erbB2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Metastatic lymph node gene 19 protein, Receptor... |
| Ursprungsart: | human |
| MW: | 72.3 kD |
ab 504,00 €
Anti-HER2/ErbB2/CD340 Monoclonal Recombinant Antibody
Artikelnummer: E-AN300004P.100
ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with...
| Schlagworte: | HER2, CD340, ERBB2, MLN 19, p185erbB2, EC=2.7.10.1, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Metastatic lymph node... |
| Anwendung: | IHC (paraffin), FCM, ICC/IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 182,00 €
Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Monoclonal...
Artikelnummer: E-AN300005L.100
ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with...
| Schlagworte: | HER2, CD340, ERBB2, MLN 19, p185erbB2, EC=2.7.10.1, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Metastatic lymph node... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 182,00 €
Lapatinib
Artikelnummer: Cay11493-5
Lapatinib is a dual inhibitor of the EGF receptor (EGFR) and ErbB2 (IC50s = 19 and 3 nM, respectively). It inhibits the growth of EGFR-overexpressing A431 skin cancer and ErbB2-overexpressing SK-BR-3 breast cancer cells (IC50s = 0.14 and 0.124 µM, respectively). Lapatinib also inhibits the growth of ErbB2-amplified...
| Schlagworte: | GSK 572016, GW 572016,... |
| Anwendung: | EGFR / HER2 inhibitor |
| CAS | 231277-92-2 |
| MW: | 581.1 D |
ab 85,00 €
Afatinib
Artikelnummer: Cay11492-5
Afatinib is an irreversible inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 (IC50s = 0.5 and 14 nM, respectively). It increases the cytotoxicity of adriamycin in a concentration-dependent manner in multidrug-resistant A549T lung cancer cells overexpressing P-glycoprotein. Afatinib (20 mg/kg) reduces...
| Schlagworte: | BIBW 2992,... |
| Anwendung: | EGFR / HER2 kinase inhibitor |
| CAS | 850140-72-6 |
| MW: | 485.9 D |
ab 40,00 €
Anti-phospho-ERBB2 (Tyr1112)
Artikelnummer: CSB-PA761682.100
Protein function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor....
| Schlagworte: | Anti-phospho-HER2, Anti-phospho-CD340, Anti-phospho-ERBB2, Anti-phospho-MLN 19, Anti-phospho-p185erbB2, EC=2.7.10.1,... |
| Anwendung: | ELISA, WB |
| Spezies-Reaktivität: | human |
340,00 €