Produkte von Indigo Biosciences
Indigo Biosciences, Inc. wurde im Jahr 2005 in State College, Pennsylvania von Dr. Jack Vanden Heuvel und Dr. Blake Peterson gegründet. Das biowissenschaftliche Unternehmen konzentriert sich auf Produkte und Dienstleistungen im Bereich in vitro-Toxikologie und Kernrezeptoren. Diese Rezeptoren stellen eine wichtige Klasse von therapeutischen Wirkstoffzielen dar. Hierbei sind quantitative Aktivitätsassays noch immer eine besondere Herausforderung für die Biotechnologie. Die beiden Gründer des Unternehmens sind international anerkannte Spezialisten auf diesem Gebiet und nutzten ihre gesammelte Expertise in der Kernrezeptorbiologie, Toxikologie, medizinischer Chemie und Molekularbiologie, um die Technologie-Plattform für diese Produkte zu entwickeln.
Mehr Informationen unter: www.indigobiosciences.com
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OXTR Reporter Assay System (human)
Artikelnummer: IB-IB35002
This is an all-inclusive cell-based luciferase reporter assay kit targeting the the Human Oxytocin Receptor (OXTR). INDIGO's ADRB1 reporter assay utilizes proprietary mammalian cells that have been engineered to provide constitutive expression of the OXTR. In addition to OXTR Reporter Cells, this kit provides two...
| Schlagworte: | OT-R, OXTR, Oxytocin receptor |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | dog |
3.803,00 €
PPARgamma (human) Reporter Assay Kit
Artikelnummer: IB-IB00101
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human peroxisome proliferator-activated receptor gamma (NR1C3), a ligand-dependent transcription factor commonly referred to as PPARG or PPARgamma. INDIGO's reporter cells include...
| Schlagworte: | NR1C3, PPARG, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, Peroxisome proliferator-activated receptor gamma |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
AhR (human) Assay Kit
Artikelnummer: IB-IB06001
INDIGO's Aryl Hydrocarbon Receptor (AhR) Reporter Cells include the luciferase reporter gene functionally linked to an AhR-responsive promoter. Thus, quantifying changes in luciferase expression in the treated reporter cells provides a sensitive surrogate measure of the changes in AhR activity. The principle...
| Schlagworte: | Aryl Hydrocarbon Receptor (human) Assay Kit, AHR, AhR, BHLHE76, bHLHe76, Ah receptor, Aryl hydrocarbon receptor, Class E... |
| Anwendung: | Functional activity screening |
ab 1.448,00 €
ERalpha (human) Reporter Assay Kit
Artikelnummer: IB-IB00401
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the full-length human estrogen receptor 1 (NR3A1), a ligand-dependent transcription factor commonly referred to as ERalpha. INDIGO's reporter cells include the luciferase reporter gene...
| Schlagworte: | ER, ESR, ESR1, ER-alpha, Estrogen receptor, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
Nrf2 (Human) Reporter Assay System
Artikelnummer: IB-IB10001
Protein function: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating...
| Schlagworte: | NRF2, HEBP1, NFE2L2, NFE2-related factor 2, NF-E2-related factor 2, Nuclear factor erythroid 2-related factor 2, Nuclear... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
PPARalpha (human) Reporter Assay Kit
Artikelnummer: IB-IB00111
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human peroxisome proliferator-activated receptor alpha (NR1C1), a ligand-dependent transcription factor commonly referred to as PPARA or PPARalpha. INDIGO's reporter cells include...
| Schlagworte: | NR1C1, PPARA, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, Peroxisome proliferator-activated receptor alpha |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
FXR (human) Reporter Assay Kit
Artikelnummer: IB-IB00601-32
This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human farnesoid X receptor (NR1H4), a ligand-dependent transcription factor commonly referred to as FXR. INDIGO's reporter cells include the luciferase reporter gene...
| Schlagworte: | BAR, NR1H4, Bile acid receptor, Farnesol receptor HRR-1, RXR-interacting protein 14, Farnesoid X-activated receptor,... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
ERbeta (human) Reporter Assay Kit
Artikelnummer: IB-IB00411
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the full-length human estrogen receptor 2 (NR3A2), a ligand-dependent transcription factor commonly referred to as ERbeta. INDIGO's reporter cells include the luciferase reporter gene...
| Schlagworte: | ESR2, ESTRB, ER-beta, Estrogen receptor beta, Nuclear receptor subfamily 3 group A member 2 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
RARbeta (human) Reporter Assay Kit
Artikelnummer: IB-IB02101
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, beta (NR1B2), a ligand-dependent transcription factor commonly referred to as RARB or RARbeta. INDIGO's reporter cells include the luciferase reporter...
| Schlagworte: | HAP, RARB, RAR-beta, RAR-epsilon, HBV-activated protein, Retinoic acid receptor beta, Nuclear receptor subfamily 1 group B... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
PXR (human) Reporter Assay Kit
Artikelnummer: IB-IB07001
Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...
| Schlagworte: | SXR, PXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
RARalpha (human) Reporter Assay Kit
Artikelnummer: IB-IB02201
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, alpha (NR1B1), a ligand-dependent transcription factor commonly referred to as RARA or RARalpha. INDIGO's reporter cells include the luciferase...
| Schlagworte: | RARA, NR1B1, RAR-alpha, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1 |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €
RORa (Human) Reporter Assay System
Artikelnummer: IB-IB04011
Protein function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid,...
| Schlagworte: | RORA, NR1F1, Nuclear receptor ROR-alpha, Nuclear receptor RZR-alpha, RAR-related orphan receptor A, Retinoid-related... |
| Anwendung: | Functional activity screening |
| Spezies-Reaktivität: | human |
ab 1.448,00 €