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JNJ-38877605
JNJ-38877605

Artikelnummer: SYN-1047-M001

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. JNJ38877605 is an orally bio-available, small-molecule, c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (c-MET enzyme and Phospho-MET IC(50) values of 4nM and 50nM, respectively) and highly specific (selective over 229...
Schlagworte: JNJ38877605
Anwendung: c-MET inhibitor
CAS 943540-75-8
MW: 377,4 D
ab 119,00 €
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JNJ-38877605
JNJ-38877605

Artikelnummer: Cay27650-10

JNJ-38877605 is an ATP-competitive inhibitor of Met kinase (IC50 = 4 nM). It is at least 600-fold selective for Met in a panel of approximately 250 tyrosine and serine-threonine kinases. JNJ-38877605 inhibits the growth of cancer cell lines with MET gene amplification (IC50s = 11-50 nM) but has no effect on the...
Schlagworte: 6-[difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]-quinoline
Anwendung: ATP-competitive Met kinase (hepatocyte growth factor receptor) inhibitor
CAS 943540-75-8
MW: 377.4 D
ab 115,00 €
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