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Nilotinib, Hydrochloride Salt, Monohydrate
Artikelnummer: LC-N-8266_250mg
Soluble in DMSO. Nilotinib, a novel, selective BCR-ABL inhibitor, fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib. Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC50 < 30 nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL...
| Schlagworte: | AMN-107 |
| Anwendung: | Antineoplastic, Tyrosine kinase inhibitor |
| CAS | 923288-90-8 |
| MW: | 584 D |
ab 92,00 €
Nilotinib (hydrochloride hydrate)
Artikelnummer: Cay36628-1
Nilotinib is an inhibitor of wild-type and mutant Bcr-Abl (IC50s = 15 and 9-400 nM, respectively). It is selective for wild-type and mutant Bcr-Abl over Src and LYN (IC50s = >5,000 nM for both). Nilotinib inhibits Bcr-Abl autophosphorylation and cell proliferation in Ba/F3 cells expressing wild-type or mutant...
| Schlagworte: | 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzamide,... |
| Anwendung: | Bcr-Abl inhibitor |
| CAS | 923288-90-8 |
| MW: | 584 D |
ab 69,00 €
